35069-95-5

Upstream product

• 1008-89-5 2-phenylpyridine 
• 77-78-1 dimethyl sulfate 
• 873383-11-0 6-bromo-1-methyl-1,2-dihydropyridin-2-one 
• 98-80-6 phenylboronic acid 
• 626-05-1 2,6-Dibromopyridine 
• 27992-32-1 6-bromo-2-pyridone 
• 694-85-9 1-methyl-2-pyridone 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 128127-16-2 N-phenyl-2-methyl-1-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-exo-dicarboximide 
• 128127-16-2 N-phenyl-2-methyl-1-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide 
• 139004-70-9 1-methyl-6-(4-nitrophenyl)-3,5-dinitro-2-pyridone 
• 139004-82-3 3-nitro-2-(4-nitrophenyl)-6-phenylpyridine 
• 139004-75-4 3-nitro-2-(4-nitrophenyl)-5,6,7,8-tetrahydroquinoline 

Relevant academic research and scientific papers

A directing group free Pd(ii)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

A Pd(ii)-catalysed direct desulfitative arylation was realized at the C6-position of the 2-pyridone scaffold. Aryl sulfonyl chloride was used as an alternative arylating agent. The required site-selectivity occurred without the strategic installation of a heteroatom containing directing group. Preliminary mechanistic studies revealed that radical species were involved during this process.

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.

Nucleophilic reaction upon electron-deficient pyridone derivatives. XIII. Regioselective synthesis of 2-substituted 3-nitropyridines by one-pot reaction of either 4- or 6-substituted 1-methyl-3,5-dinitro-2-pyridones with ketones and ammonia

A one-pot synthesis of 2-substituted 3- nitropyridines was developed by a ring transformation of 6- or 4-substituted 1-methyl-3,5-dinitro-2-pyridones (2 or 3) with ammonia and enamines derived from ketones. Some intermediates having a 2,6-diazabicyclo[3.3.1]nonane skeleton were isolated from reactions of 3. The ring transformation proceeds via an addition-addition-elimination-elimination mechanism. Few competitive isomeric by-products, 4-substituted 3-nitropyridines and 4-nitroanilines, were formed. All the 2 substrates showed good reactivity, but the 3 substrates having electron-withdrawing substituents were less reactive and selective. 1,4,6-Trimethyl-3,5-dinitro-2-pyridone did not give any products. The selectivity is interpreted in terms of differences of thermodynamic (main selection rule B) and kinetic stability (minor selection rule A) between the possible bicyclic intermediates which are expected to be formed via the mechanism.