873383-11-0

Basic information

• Product Name: 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
• Synonyms: 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;6-Bromo-1-methylpyridine-2(1H)one;2(1H)-Pyridinone, 6-broMo-1-Methyl-;6-bromo-1-methylpyridin-2-one;6-Bromo-1-methyl-1,2-dihydropyridin-2-one;6-Bromo-1-methylpyridin-2(1H)
• CAS NO: 873383-11-0
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• Mol File: 873383-11-0.mol

Chemical Properties

• Boiling Point: 287.109°C at 760 mmHg
• Flash Point: 127.439°C
• Appearance: /
• Density: 1.665g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -0.98±0.62(Predicted)
• CAS DataBase Reference: 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(873383-11-0)
• EPA Substance Registry System: 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE(873383-11-0)

Safety Data

• Hazardous Substances Data: 873383-11-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its presence in the molecular structure of these compounds aids in enhancing their therapeutic properties and effectiveness in treating various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE is employed as a crucial component in the production of agrochemicals. Its reactivity and structural features make it an essential building block for the synthesis of compounds that can help improve crop protection and yield.
Used in Fine Chemicals Manufacturing:
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE is utilized as a vital ingredient in the manufacturing of fine chemicals. Its unique properties and reactivity contribute to the creation of specialty products that have specific applications in various industries, such as fragrances, dyes, and other chemical intermediates.
Used in Organic Synthesis:
As a versatile building block, 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE is used in organic synthesis to create a wide range of chemical compounds. Its bromine and methyl groups enhance its reactivity, allowing for the development of diverse molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and specialty products.

InChI:InChI=1/C6H6BrNO/c1-8-5(7)3-2-4-6(8)9/h2-4H,1H3

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 77-78-1 dimethyl sulfate 
• 27992-32-1 6-bromo-2-pyridone 
• 74-88-4 methyl iodide 
• 1352724-65-2 (4-Fluorophenyl)(3'-hydroxy-1'-(4-methoxybenzyl)-[1,4'-bipiperidin]-4-yl)methanone 
• 19798-81-3 2-Amino-6-bromopyridine 
• 27992-32-1 6-bromo-2-hydroxypyridine 

Downstream Products

• 626-05-1 2,6-Dibromopyridine 
• 2766-64-5 2,3,5,6-tetrabromopyridine 
• 35069-95-5 1-methyl-6-phenylpyridin-2(1H)-one 

Relevant articles and documents

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MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

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BTK INHIBITOR

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NEW COMPOUNDS

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Asymmetric Homogeneous Hydrogenation of 2-Pyridones

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To identify suitable lipophilic compounds having high potency and selectivity for vesicular acetylcholine transporter (VAChT), a heteroaromatic ring or a phenyl group was introduced into the carbonyl-containing scaffold for VAChT ligands. Twenty new compounds with ALogD values between 0.53 and 3.2 were synthesized, and their in vitro binding affinities were assayed. Six of them (19a, 19e, 19g, 19k, and 24a-b) displayed high affinity for VAChT (Ki = 0.93-18 nM for racemates) and moderate to high selectivity for VAChT over σ1 and σ2 receptors (Ki = 44-4400-fold). These compounds have a methyl or a fluoro substitution that provides the position for incorporating PET radioisotopes C-11 or F-18. Compound (-)-[11C]24b (Ki = 0.78 nM for VAChT, 1200-fold over σ receptors) was successfully synthesized and evaluated in vivo in rats and nonhuman primates. The data revealed that (-)-[11C]24b has highest binding in striatum and has favorable pharmacokinetics in the brain.