3508-84-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(trichloromethyl)cyclohexan-1-ol is utilized as a key intermediate in the production of pharmaceuticals, playing a critical role in the synthesis of various medicinal compounds. Its unique chemical structure allows for the development of drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(trichloromethyl)cyclohexan-1-ol is employed as an intermediate for the synthesis of pesticides and other agricultural chemicals. Its contribution to the development of these products helps enhance crop protection and yield.
Used in Organic Compounds Synthesis:
1-(trichloromethyl)cyclohexan-1-ol is used as an intermediate in the synthesis of a range of organic compounds, contributing to the creation of diverse chemical products with various applications across different industries.
Used as a Solvent in Chemical Processes:
1-(trichloromethyl)cyclohexan-1-ol also serves as a solvent in certain chemical processes, facilitating reactions and aiding in the production of specific chemical entities. Its solvent properties are valuable in achieving desired outcomes in chemical synthesis.

InChI:InChI=1/C7H11Cl3O/c8-7(9,10)6(11)4-2-1-3-5-6/h11H,1-5H2

Upstream product

• 56-23-5 tetrachloromethane 
• 108-94-1 cyclohexanone 
• 2146-66-9 trichloromethyl lithium 
• 85695-30-3 trimethyl[(1-(trichloromethyl)cyclohexyl)oxy]silane 
• 650-51-1 sodium trichloroacetate 
• 109-87-5 Dimethoxymethane 
• 67-66-3 chloroform 
• 105-57-7 diethyl acetal 
• 60-29-7 diethyl ether 

Downstream Products

• 118727-99-4 chloro-(2,2,2-trichloro-1,1-dimethyl-ethoxy)-(1-trichloromethyl-cyclohexyloxy)-phosphine 
• 872288-70-5 1-isobutoxy-cyclohexanecarboxylic acid 
• 88348-80-5 1-chloro-2-dichloromethylidenecyclohexane 
• 117043-27-3 dichloro-(1-trichloromethyl-cyclohexyloxy)-phosphine 
• 19444-36-1 cyclohexenecarboxylic acid chloroethyl ester 
• 19444-35-0 2-chloroethyl 1-chlorocyclohexane-1-carboxylate 
• 766-66-5 2-chlorocycloheptanone 
• 25882-61-5 1-chlorocyclohexanecarboxylic acid 
• 129256-45-7 1-(1H-Benzoimidazol-2-ylamino)-cyclohexanecarboxylic acid 
• 636-82-8 cyclohexene-1-carboxylic acid 
• 108-94-1 cyclohexanone 
• 100-44-7 benzyl chloride 
• 1122-55-0 (dichloromethylene)cyclohexane 
• 1121-50-2 1-(chloromethylene)cyclohexane 

Relevant academic research and scientific papers

Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes

Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.

Ring expansion/homologation-aldehyde condensation cascade using tert-trihalomethylcarbinols

Treatment of cyclic tert-trihalomethylcarbinols with CrCl2 in THF/HMPA in the presence of aryl or aliphatic aldehydes initiates a cascade sequence of one carbon ring expansion-olefination affording conjugated exocyclic ketones. Acyclic tert-trihalomethylcarbinols undergo a comparable cascade of one carbon homologation-olefination.

Decomposition of sodium trichloroacetate in the presence of quaternary ammonium under microwave irradiation: A convenient one-pot synthesis of α-hydroxy acids in water

A good yielding phase-transfer-catalyzed procedure for one-pot preparation of α-hydroxy acids from carbonyl compounds and sodium trichloroacetate by in situ addition and hydrolysis under microwave irradiation is described. Decomposition of sodium trichloroacetate is strongly accelerated by the presence of quaternary ammonium. The reaction can be conducted in water. Copyright Taylor & Francis Group, LLC.

Direct electroreduction or use of an electrogenerated base : Two ways for the coupling of polyhalogenated compounds with aldehydes or ketones

The electrochemical coupling of polyhalogenated compounds with carbonyl compounds is achieved in two ways. A carbanion RX(n)- is generated either by the direct electroreduction of RX(n)Cl or by deprotonation of RX(n)H. In this latter case the base Ph- is electrogenerated by reduction of iodobenzene. All electrolysis were carried out in an undivided cell fitted with a cadmium-coated cathode and an aluminium or magnesium sacrificial anode.

PRODUCTION OF 1,1,1-TRIHALOGENO-2-ALKANOLS AND SOME OF THEIR PROPERTIES

The reaction of acyclic and carbocyclic carbonyl compounds with haloforms was studied in liquid ammonia and dimethylformamide in the presence of basic catalysts (t-BuOK, KOH).As a result of the reaction 1,1,1-trihalogeno-2-alkanols were obtained.They were used for the synthesis of 1,1,1-trihalogeno-2-methoxyalkanes, 1,1-dibromoalkenes, 1,1-dichloro-2-methoxyalkenes, and alkyl mono- and dichloromethyl ketones.

TRICHLOROMETHYL ANION CHEMISTRY FROM TRIMETHYLSILYL TRICHLOROACETATE

The reaction of trimethylsilyl trichloroacetate with aldehydes and ketones in the presence of fluoride ion gives the trichloromethyl adducts.With potassium fluoride the reaction with cyclohexenone and crotonaldehyde results in clear 1,2 addition.

TRIMETHYLSILYL TRICHLOROACETATE: A NEW REAGENT FOR SALT-FREE SILYLATIONS

Trimethylsylil trichloroacetate (1) is a convenient reagent for the silylation of phenols, carboxylic acids, mercaptans, amides, acetylenes, and β-keto esters, while the reaction of 1 with aldehydes and ketones affords silylated trichloromethyl carbinols (5).

Chain Reactions Induced by Cathodic Reduction

Cathodic reduction of a system comprising carbon tetrachloride, chloroform, and an aldehyde led to an effective anionic chain reaction.The best current efficiency observed was about 1*104 percent .Such a chain reaction is an effective synthetic method for 1,1,1-trichloro-2-alkanols.The reaction system consisting of methyl trichloroacetate, methyl dichloroacetate, and an aldehyde and several other systems also exhibited a similar pattern of chain reaction.