434960-42-6

Basic information

• Product Name: 5-bromo-6-fluoro-1H-indole
• Synonyms: 5-bromo-6-fluoro-1H-indole;5-Bromo-6-fluoro indole
• CAS NO: 434960-42-6
• Molecular Formula: C₈H₅BrFN
• Molecular Weight: 214.0344032
• Mol File: 434960-42-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 315.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.750±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.44±0.30(Predicted)
• CAS DataBase Reference: 5-bromo-6-fluoro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-6-fluoro-1H-indole(434960-42-6)
• EPA Substance Registry System: 5-bromo-6-fluoro-1H-indole(434960-42-6)

Safety Data

• Hazardous Substances Data: 434960-42-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-6-fluoro-1H-indole is a synthetic, organic compound identified by its IUPAC name. Its chemical formula is C8H5BrFN, indicating it contains carbon, hydrogen, bromine, fluorine, and nitrogen atoms. 5-bromo-6-fluoro-1H-indole belongs to the class of organic compounds known as indoles, which are characterized by an indole ring system. 5-Bromo-6-fluoro-1H-indole is used as a pharmaceutical intermediate and in the field of material science for making more complex molecules. Its molecular weight is around 227.04 g/mol. As a bromo-fluoro-indole, it participates in various chemical reactions, exhibiting properties particular to bromines and fluorines substituted on an indole ring. However, its specific reactions, behavior, and applications can vary widely depending on the exact context and conditions. It's also important to handle this compound with caution and according to safety guidelines, as its health effects have not been fully studied.

Upstream product

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Downstream Products

• 1427358-21-1 6-fluoro-1H-indole-5-carbonitrile 
• 1467057-27-7 6-fluoro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid 
• 1638759-63-3 methyl 5-bromo-6-fluoro-1H-indole-3-carboxylate 
• 1589004-60-3 C₁₄H₉BrFNO₂S 
• 1589004-66-9 C₂₀H₂₃FN₂O₃S₂ 

Relevant articles and documents

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

TRICYCLIC SULFONAMIDE DERIVATIVES

The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of pain.

BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS

The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula (I), pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.