351-33-7

Upstream product

• 79-04-9 chloroacetyl chloride 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 

Downstream Products

• 875656-36-3 N-(4-chloro-3-trifluoromethylphenyl)-2-[(R)-1-(3,4-dimethoxyphenyl)-ethylamino]-acetamide 
• 352347-24-1 2-(4-bromo-phenoxy)-N-(4-chloro-3-trifluoromethyl-phenyl)acetamide 
• 847608-67-7 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[4-(5-hydroxy-1H-tetrazol-1-yl)phenyl]oxy}acetamide 
• 847606-73-9 N'-[4-chloro-3-(trifluoromethyl)phenyl]-N-[3-(1H-tetrazol-1-yl)phenyl]glycinamide 
• 847606-76-2 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[3-(1H-tetrazol-1-yl)phenyl]thio}acetamide 
• 847608-10-0 tert-butyl 2-(4-(2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-2-oxoethoxy)phenyl)-1H-indole-1-carboxylate 
• 847606-77-3 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[(4-pyrimidin-5-ylphenyl)oxy]acetamide 

Relevant academic research and scientific papers

N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles

Transition metal-free catalytic methods for access to 2-arylindole compounds.

N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles

A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported. Umpolung: N-heterocyclic carbene catalysis is used for the convergent and efficient transition-metal-free synthesis of 2-aryl-indoles. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent is central to this successful strategy. The reaction exhibits high yields and a wide scope, and it has been applied to a streamlined synthesis of a kinase inhibitor.

Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics

Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.

HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS

Heterocyclic diamine compounds of formula (I) are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, d

C-KIT MODULATORS AND METHODS OF USE

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention

GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHIBITORS

The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.