847608-10-0

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 118-92-3 anthranilic acid 
• 164226-32-8 2-(tert-butyloxycarbonyl)aminobenzyl alcohol 
• 243844-36-2 tert-butyl (2-(chloromethyl)phenyl)-carbamate 
• 351-33-7 [(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 

Relevant academic research and scientific papers

N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles

Transition metal-free catalytic methods for access to 2-arylindole compounds.

N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles

A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported. Umpolung: N-heterocyclic carbene catalysis is used for the convergent and efficient transition-metal-free synthesis of 2-aryl-indoles. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent is central to this successful strategy. The reaction exhibits high yields and a wide scope, and it has been applied to a streamlined synthesis of a kinase inhibitor.