351-84-8

Basic information

• Product Name: N-(4-fluorophenyl)ethanethioamide
• CAS NO: 351-84-8
• Molecular Formula: C₈H₈FNS
• Molecular Weight: 169.2192
• Mol File: 351-84-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 223.7°C at 760 mmHg
• Flash Point: 89.1°C
• Density: 1.257g/cm³
• Vapor Pressure: 0.0951mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: N-(4-fluorophenyl)ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)ethanethioamide(351-84-8)
• EPA Substance Registry System: N-(4-fluorophenyl)ethanethioamide(351-84-8)

Safety Data

• Hazardous Substances Data: 351-84-8(Hazardous Substances Data)

Upstream product

• 158364-41-1 (E)-1-(4-fluorophenyl)ethan-1-one oxime 
• 371-40-4 4-fluoroaniline 
• 351-83-7 4'-fluoroacetanilide 

Downstream Products

• 399-73-5 6-fluoro-2-methylbenzo[d]thiazole 
• 933749-06-5 6-fluorobenzo[d]thiazole-2-carbaldehyde 

Relevant articles and documents

Study of the structural and conformational properties of fluoro-substituted thioacetanilide derivatives

The assessment of the influence of a halogen atom in the structural, vibrational and conformational properties of o-, m- and p-fluorothioacetanilide derivatives was achieved through different methodologies. For all compounds infrared (FTIR) and nuclear ma

Dehydrative Beckmann rearrangement and the following cascade reactions

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.

Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents

Based on our previous results and literature precedence, a series of 2-anilinopyridinyl-benzothiazole Schiff bases were rationally designed by performing molecular modeling experiments on some selected molecules. The binding energies of the docked molecules were better than the E7010, and the Schiff base with trimethoxy group on benzothiazole moiety, 4y was the best. This was followed by the synthesis of a series of the designed molecules by a convenient synthetic route and evaluation of their anticancer potential. Most of the compounds have shown significant growth inhibition against the tested cell lines and the compound 4y exhibited good antiproliferative activity with a GI50 value of 3.8?μM specifically against the cell line DU145. In agreement with the docking results, 4y exerted cytotoxicity by the disruption of the microtubule dynamics by inhibiting tubulin polymerization via effective binding into colchicine domain, comparable to E7010. Detailed binding modes of 4y with colchicine binding site of tubulin were studied by molecular docking. Furthermore, 4y induced apoptosis as evidenced by biological studies like mitochondrial membrane potential, caspase-3, and Annexin V-FITC assays.