3511-34-0

Upstream product

• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 14464-29-0 N-acetoxysuccinimide 
• 141-97-9 ethyl acetoacetate 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 79966-46-4 5-((E)-2-Furan-2-yl-vinyl)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 79966-45-3 5-[(E)-2-(4-Methoxy-phenyl)-vinyl]-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 79966-41-9 1-phenyl-5-bromomethyl-4-ethoxycarbonyl-3-methylpyrazol 
• 79966-40-8 1-benzyl-5-bromomethyl-4-ethoxycarbonyl-3-methylpyrazol 
• 79966-44-2 1-phenyl-4-ethoxycarbonyl-3-methyl-5-styrylpyrazole 
• 79966-43-1 1-benzyl-4-ethoxycarbonyl-3-methyl-5-styrylpyrazole 

Relevant academic research and scientific papers

Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides

A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; b) a bioinspired (3+2)-cycloaddition of the aziridine onto an alkene; and c) installation of the acetyltetramic acid by an unprecedented tandem carbonylative lactamization/N?O cleavage of a bromoisoxazole.

Synthesis of 2-substituted 4,5-dihydro-4-oxo-3-furancarboxylates using acylative intramolecular cyclization of sulfonium salts

A simple and efficient synthesis of 4,5-dihydro-4-oxo-3-furancarboxylates using an acylative intramolecular cyclization of sulfonium salts is described. The reaction involved the efficient formation of a mixed anhydride between a linear carboxylic acid and trifluoroacetic anhydride in the presence of N-methylimidazole, followed by the sequential conversion into a highly reactive acylammonium species in situ. This procedure is easily handled, uses readily available inexpensive reagents, and provides a variety of 2-substituted 4,5-dihydro-4-oxo-3-furancarboxylates.

GPR52 MODULATOR COMPOUNDS

The disclosures herein relate to novel compounds of Formula (1): and salts thereof, wherein X, Y, R1, R2, R3 and R4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.

SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.