3511-34-0Relevant articles and documents
Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides
Zhurakovskyi, Oleksandr,Türkmen, Yunus E.,L?ffler, Lorenz E.,Moorthie, Vijayalakshmi A.,Chen, C. Chun,Shaw, Michael A.,Crimmin, Mark R.,Ferrara, Marco,Ahmad, Mushtaq,Ostovar, Mehrnoosh,Matlock, Johnathan V.,Aggarwal, Varinder K.
, p. 1346 - 1350 (2018)
A convergent, nine-step (LLS), enantioselective synthesis of α-cyclopiazonic acid and related natural products is reported. The route features a) an enantioselective aziridination of an imine with a chiral sulfur ylide; b) a bioinspired (3+2)-cycloaddition of the aziridine onto an alkene; and c) installation of the acetyltetramic acid by an unprecedented tandem carbonylative lactamization/N?O cleavage of a bromoisoxazole.
GPR52 MODULATOR COMPOUNDS
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Page/Page column 35; 57-58, (2021/09/17)
The disclosures herein relate to novel compounds of Formula (1): and salts thereof, wherein X, Y, R1, R2, R3 and R4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.