35114-02-4Relevant academic research and scientific papers
CFBSA: a novel and practical chlorinating reagent
Lu, Zehai,Li, Qingwei,Tang, Minghua,Jiang, Panpan,Zheng, Hao,Yang, Xianjin
supporting information, p. 14852 - 14855 (2015/10/06)
A structurally simple, highly reactive chlorinating reagent, N-chloro-N-fluorobenzenesulfonylamine (CFBSA), was conveniently prepared from inexpensive Chloramine B in high yield. A wide range of substrates were chlorinated with it to obtain products in good to high yields and appropriate selectivity.
Isotope-effect profiles in the oxidative N-demethylation of N,N-dimethylanilines catalysed by lignin peroxidase and a chemical model
Baciocchi, Enrico,Gerini, M. Francesca,Lanzalunga, Osvaldo,Lapi, Andrea,Lo Piparo, Maria Grazia,Mancinelli, Simona
, p. 2305 - 2310 (2007/10/03)
Lignin peroxidase catalyses the oxidative N-demethylation of ring-substituted N,N-dimethylanilines by an electron-transfer mechanism whereby an anilinium radical cation is formed which is then deprotonated by the enzyme. Information on the nature of the basic centre which deprotonates the radical cation has been obtained by determining the KDIE profile (plot of kH/kD vs. the pKa of the aniline radical cations) for a number of ring-substituted N,N- bis(dideuteriomethyl)-anilines. From the bell-shaped curve it has been estimated that the pKa of the proton-abstracting base is about 7. Interestingly, almost the same value has been obtained when the same type of study has been carried out using a water-soluble model compound: 5,10,15,20-tetraphenyl-21H,23H-porphine-p,p′,p″, p?-tetrasulfonic acid iron(III) chloride. This is a strong indication that the radical cation is deprotonated by the same species in the enzymatic and in the chemical reactions. It is suggested that this species is the reduced iron-oxo complex.
