35115-15-2

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 105-37-3 Ethyl propionate 
• 97139-96-3 2'-propanoyloxyacetophenone 

Downstream Products

• 14736-30-2 2-ethyl-4H-chromen-4-one 
• 70423-63-1 2-(3-ethyl-isoxazol-5-yl)-phenol 
• 118-93-4 o-hydroxyacetophenone 
• 5751-48-4 2-methylchromone 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 16636-62-7 1-(2'-hydroxyphenyl)butane-1,3-dione 
• 525-82-6 FLAVONE 
• 5751-49-5 2-isopropyl-4H-chromen-4-one 
• 7250-94-4 o-acetoxyacetophenone 
• 4010-33-7 2-acetylphenyl benzoate 
• 4143-74-2 4'-methoxyflavone 
• 4143-72-0 1-(2-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 4010-26-8 2-acetylphenyl-4-methyl benzoate 
• 36695-15-5 1-[2-(4-nitrobenzoyloxy)-phenyl]-ethanone 

Relevant academic research and scientific papers

Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus

Small molecules active in the pathogenic bacterium Staphylococcus aureus are valuable tools for the study of its basic biology and pathogenesis, and many molecules may provide leads for novel therapeutics. We have previously reported a small molecule, 1, which activates endogenous heme biosynthesis in S. aureus, leading to an accumulation of intracellular heme. In addition to this novel activity, 1 also exhibits toxicity towards S. aureus growing under fermentative conditions. To determine if these activities are linked and establish what features of the molecule are required for activity, we synthesized a library of analogs around the structure of 1 and screened them for activation of heme biosynthesis and anaerobic toxicity to investigate structure-activity relationships. The results of this analysis suggest that these activities are not linked. Furthermore, we have identified the structural features that promote each activity and have established two classes of molecules: activators of heme biosynthesis and inhibitors of anaerobic growth. These molecules will serve as useful probes for their respective activities without concern for the off target effects of the parent compound.

Ruthenium-NHC-catalyzed asymmetric hydrogenation of flavones and chromones: General access to enantiomerically enriched flavanones, flavanols, chromanones, and chromanols

Two to four! Readily available flavones and chromones were efficiently converted into four valuable chiral classes of O-heterocycles - flavanones, chromanones, flavanols, and chromanols - by means of an enantioselective Ru/NHC-catalyzed hydrogenation process (see scheme; NHC=N-heterocyclic carbene, PCC=pyridinium chlorochromate). Copyright

A new metal complex promoted system for highly selective synthesis of 4H-chromen-4-ones (chromones)

Co(III)(salpr)(OH), a six coordinate cobalt Schiff base complex, promotes the highly selective conversion of 1-(o-hydroxyaryl)-1,3-diketones to 4H-chromen-4-ones under neutral conditions.