35120-33-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE is used as a building block for the synthesis of pharmaceuticals, specifically for the development of drugs that target central nervous system disorders. Its unique structure and properties make it a valuable component in the creation of these therapeutic agents.
Used in Chemical Industry:
In the chemical industry, (S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE is used in the synthesis of various organic compounds, contributing to the development of new chemical entities with potential applications in different fields.
Used as a Reagent in Chemical Reactions:
(S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE is utilized as a reagent in chemical reactions, facilitating specific transformations and providing a means to achieve desired outcomes in the synthesis of complex molecules.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
(S)-2-(CHLOROMETHYL)PYRROLIDINE HYDROCHLORIDE is employed as a chiral auxiliary in asymmetric synthesis, playing a crucial role in the production of enantiomerically pure compounds, which are essential in various applications, including pharmaceuticals and agrochemicals, where the stereochemistry of a molecule can significantly impact its biological activity and efficacy.

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 121451-45-4 (S)-bis<2-<<2-(chloromethyl)-1-pyrrolidinyl>carbonyl>phenyl> disulphide 
• 61350-66-1 (S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester 

Relevant academic research and scientific papers

Pd(II) Complexes with Chelating Phosphinoferrocene Diaminocarbene Ligands: Synthesis, Characterization, and Catalytic Use in Pd-Catalyzed Borylation of Aryl Bromides

We developed a novel, straightforward route toward Pd(II)-aminocarbene complexes bearing a P-chelating phosphinoferrocenyl substituent based on a three-component reaction of 1′-(diphenylphosphino)-1-isocyanoferrocene (1) with [PdCl2(cod)] (cod = cycloocta-1,5-diene) and nucleophilic amines. Depending on the type of the amine, the reaction produced acyclic diaminocarbenes and their saturated (imidazolin-2-ylidene) and unsaturated (imidazol-2-ylidene) cyclic counterparts (NHCs). Using (S)-2-(chloromethyl)pyrrolidine as the nucleophile, this method afforded a separable pair of stable diastereomeric bicyclic imidazolin-2-ylidene carbenes with different configurations of the planar-chiral ferrocene unit. The prepared P-chelating carbenes were characterized using spectroscopic methods, X-ray crystallography, and DFT methods. The last were used to explain the formation of isomeric open diaminocarbenes featuring NHR groups at the wing-tip position, trends in Pd-Cl bond lengths reflecting similar trans influences of the particular carbene and phosphine donors, and the results from cyclic voltammetric measurements. Furthermore, the carbenes were used as defined (pre)catalysts in Miyaura borylation of aryl bromides with bis(pinacolato)diboron. When applying the optimized catalytic system (1 mol % Pd catalyst, KOAc as the base, 2-propanol, 85 °C), this reaction produced a range of simple and substituted arylboronate pinacol esters in high yield and without biaryl side products.

A new class of potent non-imidazole H3 antagonists: 2-Aminoethylbenzofurans

2-Aminoethylbenzofurans constitute a new class of H3 antagonists that are more rotationally constrained than most previously reported H3 antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine.