35121-60-9Relevant articles and documents
Improved preparation method of nicergoline (by machine translation)
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Paragraph 0046; 0047; 0050; 0051; 0054; 0055; 0058; 0059, (2020/05/30)
Compared the prior art,bromonicotinoyl chloride intermediate, is prepared-methoxyphenylglycinol :(1) by a reaction with an organic amine as, an acid-binding agent, to produce 10α -(2) methyl - 101010101010101010and X3B1,methoxyphenylglycinol, in a solvent, 10α - The final yield of the product can reach or above product to be 1 - suitable for large-scale ;(3) production, The, method 5 - comprises the following 5 - steps 5 - carrying out a methylation reaction 1 - with an organic, amine, as an organic amine as an acid,binding compound, in a solvent in a solvent and an inorganic base by an organic amine as an acid-binding agent in, an amide type non-protonic solvent to prepare 50% the . nylmyralyl chloride 99%, midst with an organic amine as an organic amine as an acid-binding agent. (by machine translation)
New preparation method of 10alpha-methoxy-9,10-MMDL
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Paragraph 0055; 0058; 0059; 0062; 0063; 0068, (2019/03/24)
The invention discloses a preparation method of 10alpha-methoxy-9,10-MMDL, which is high in product yield, good in product quality, simple in process and suitable for industrial production. The preparation method of 10alpha-methoxy-9,10-MMDL includes the following steps that S1, an intermediate is prepared, wherein lysergic acid and methyl alcohol are subjected to a methoxylation reaction, and after purification, the intermediate 10alpha-methoxy-9,10-dihydrolysergic acid methyl ester is obtained; S2, the intermediate 10alpha-methoxy-9,10-dihydrolysergic acid methyl ester reacts with a reductant, and after purification, 10alpha-methoxy-9,10-MMDL is obtained. By means of the preparation method of 10alpha-methoxy-9,10-MMDL, reaction conditions are mild, operation is easy, the product qualityis good, the product yield is high, the total yield reaches 75% or above, and industrial application and promotion are facilitated.
Neue nootrop wirksame Ergoline
Hempel, R.,Heidenbluth, K.,Dauth, C.,Bartsch, R.,Schmidt, I.,et al.
, p. 213 (2007/10/02)
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