10-methoxy-6-methylergoline-8beta-methanol

Base Information

• Chemical Name: 10-methoxy-6-methylergoline-8beta-methanol
• CAS No.: 35121-60-9
• Molecular Formula: C17H22 N2 O2
• Molecular Weight: 286.374
• Mol file: 35121-60-9.mol

Synonyms:Lumilysergol,10-O-methyl- (7CI); Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.;10-Methoxydihydrolysergol; 10-O-Methyllumilysergol; 10a-Methoxy-9,10-dihydrolysergol; 10a-Methoxydihydrolysergol; 10a-Methoxylumilysergol; 8b-(Hydroxymethyl)-10a-methoxy-6-methylergoline; Luol;O10-Methyllumilysergol

Chemical Property of 10-methoxy-6-methylergoline-8beta-methanol

Chemical Property:

• Vapor Pressure: 0.002Pa at 20℃
• Boiling Point: 456.8°Cat760mmHg
• PKA: 14.87±0.10(Predicted)
• Flash Point: 230.1°C
• PSA: 48.49000
• Density: 1.27g/cm³
• LogP: 1.81620
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
• Water Solubility.: 440mg/L at 20℃

Purity/Quality:

99.9% ^*data from raw suppliers

10ALPHA-METHOXY-9,10-DIHYDROLYZERGOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 10α-Methoxy-9,10-dihydrolysergol is a derivative of Lysergol and Dehydrolysergol-I which act as partial agonists and antagonists at 5-HT2A, 5-HT2C and 5-HT1B receptors, and at α1-andrenergic receptors.

Technology Process of 10-methoxy-6-methylergoline-8beta-methanol

There total 4 articles about 10-methoxy-6-methylergoline-8beta-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

methanol (67-56-1) + lysergol (602-85-7) → 10alpha-methoxy-9,10-dihydrolysergol (35121-60-9)

Guidance literature:

With sulfuric acid; at 20 - 40 ℃; for 6h; Inert atmosphere; UV-irradiation;

Reference yield:

6-methyl-8β-carboxy-10α-methoxy-ergoline → 10alpha-methoxy-9,10-dihydrolysergol (35121-60-9)

Guidance literature:

With metal chloride; at 20 - 33 ℃; for 2.5h; Large scale;

Reference yield:

D-lysergic acid (82-58-6) → 10alpha-methoxy-9,10-dihydrolysergol (35121-60-9) + 10α-methoxy-9,10-dihydrolysergic acid methylester (23495-64-9)

Guidance literature:

upstream raw materials:

D-lysergic acid

methanol

lysergol

Downstream raw materials:

1-Methyl-10alpha-methoxy-9,10-dihydrolysergol

Refernces

• 1、 -. "Synthetic method of nicergoline". Paragraph 0019-0021. . Retrieved 2020/05/30.
• 2、 -. "Synthetic method for nicergoline". Paragraph 0049; 0054. . Retrieved 2018/06/15.