22746-09-4

Basic information

• Product Name: 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE
• Synonyms: TIMTEC-BB SBB010072;4,6-DIMETHYL-2-(1-PIPERAZINYL)PYRIMIDINE;AKOS BBS-00003693;1-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE;1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE;1-(4,6-Dimethylpyrimidin-2-yl)piperazine, 4,6-Dimethyl-2-(piperazin-1-yl)-1,3-diazine;4,6-Dimethyl-2-(piperazin-1-yl)pyrimidine 98%;4,6-Dimethyl-2-(piperazin-1-yl)pyrimidine98%
• CAS NO: 22746-09-4
• Molecular Formula: C₁₀H₁₆N₄
• Molecular Weight: 192.26
• Mol File: 22746-09-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 115-118
• Boiling Point: 115-118°C 1mm
• Appearance: /
• CAS DataBase Reference: 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE(22746-09-4)
• EPA Substance Registry System: 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE(22746-09-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22746-09-4(Hazardous Substances Data)

Usage

General Description

1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE is a chemical compound that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is a piperazine derivative with a pyrimidine ring substitution, and the dimethyl groups on the pyrimidine ring provide stability and enhance its pharmacological properties. 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE has been identified as a potential serotonin receptor antagonist and has shown promising results in the treatment of allergies, anxiety, and depression. Additionally, it has also been investigated for its potential antitumor activity. As a result, 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE holds significant importance in medicinal chemistry and drug development.

Upstream product

• 110-85-0 piperazine 
• 35144-22-0 4,6-dimethyl-2-methylsulfonylpyrimidine 
• 34289-60-6 4,6-dimethyl-2-hydroxy-pyrimidine hydrochloride 
• 123-54-6 acetylacetone 
• 767-15-7 2-Amino-4,6-dimethylpyrimidine 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 14001-64-0 4,6-dimethyl-2-methylsulfanyl-pyrimidine 
• 22325-27-5 4,6-dimethyl-2-meraptopyrimidine 

Downstream Products

• 1224727-24-5 C₂₁H₂₂ClF₃N₈S 
• 1224727-21-2 C₂₁H₂₂F₄N₈S 
• 1224727-22-3 C₂₂H₂₅F₃N₈OS 
• 1224727-23-4 C₂₃H₂₇F₃N₈S 
• 1224727-25-6 C₂₁H₂₂F₃N₉O₂S 
• 1224727-20-1 C₂₁H₂₃F₃N₈S 

Relevant articles and documents

Design, synthesis and evaluation of new indolylpyrimidylpiperazines for gastrointestinal cancer therapy

Human A3 adenosine receptor hA3AR has been implicated in gastrointestinal cancer, where its cellular expression has been found increased, thus suggesting its potential as a molecular target for novel anticancer compounds. Observation

Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives

A series of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives have been conveniently synthesized via Mannich reaction in good yields. Their structures were identified by IR,1H NMR,13C NMR, and elemental analysis. The preliminary bioassays showed that among 14 new compounds, the trifluoromethyl-containing compounds exhibited superior activity than the methyl-containing ones; some of the compounds displayed significant in vitro and in vivo fungicidal activity against several plant fungi and were comparable with the control Triadimefon; several compounds exhibited certain herbicidal activity against Brassica campestris; several compounds possessed favorable KARI inhibitory activity, especially 8D could be a promising KARI inhibitor for further study. The research results will provide useful information for the design and discovery of new agrochemicals with novel heterocyclic Mannich base structures containing piperazine moiety.

Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety

A series of novel acetylated piperazine-containing N-glucosides and bis(N-glucoside) 8a-i were synthesized by the nucleophilic addition of acetylated glucopyranosyl isothiocyanate with various substituted piperazines in THF with high yields. Their novel deacetylated products 9a-i were also synthesized after Me-ONa/MeOH treatment. The preliminary bioassays for 18 novel title compounds showed that several compounds have significant fungicidal activity against Fusarium omysporum, Cercospora arachidicola and Phytophthora capsici at 50 μg/mL.