35149-32-7Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
Elmenier, Fatma M.,Lasheen, Deena S.,Abouzid, Khaled A. M.
, p. 315 - 332 (2022/01/04)
Cancer is one of the most aggressive diseases characterised by abnormal growth and uncontrolled cell division. PI3K is a lipid kinase involved in cancer progression which makes it fruitful target for cancer control. 28 new morpholine based thieno[2,3-d] p
Synthesis of some new tetrahydrobenzo[b] thiophene derivatives and tetrahydrobenzo-thienopyrimidine derivatives under microwave irradiation
Abdalha,El-Kassaby, M.K. Abou,El-Regal,Ali
experimental part, p. 2811 - 2821 (2011/09/12)
2-Phenyl-5,6,7,8-tetrahydro-4H-benzothieno[2,3-d][1,3]oxazin-4-one (4) was reacted with either aliphatic or aromatic primary amines such as benzylamine, cyclohexylamine, p-toluidine, and=or p-anisidine to give carboxamide derivatives 5a-d, respectively. A
Multistep, microwave assisted, solvent free synthesis and antibacterial activity of 6-substituted-2,3,4-trihydropyrimido[1,2-c]9,10,11,12- tetrahydrobenzo[b]thieno[3,2-e]pyrimidines
Raghu Prasad, Mailavaram,Pran Kishore, Deb
, p. 776 - 779 (2008/02/08)
A novel, efficient, microwave assisted route for the synthesis of 6-substituted-2,3,4-trihydropyrimido[1,2-c]-9,10,11,12-tetrahydrobenzo[b] thieno[3,2-e]pyrimidines in good yields has been developed. The intermediates, 2-substituted-4-[3-hydroxy(propyl-1-
Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines
Prasad, Mailavaram Raghu,Rao, Akkinepalli Raghu Ram,Rao, Pamulaparthi Shanthan,Rajan, Kombu Subramanian
, p. 2119 - 2123 (2007/10/03)
A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.
3,4-Dihydrothienopyrimidines. II. Synthesis and Sodium Borohydride Reduction of 2-Substituted 4-Chloro- and 4-Unsubstituted-thienopyrimidines
Yamaguchi, Hitoshi,Ishikawa, Fumiyoshi
, p. 326 - 332 (2007/10/02)
The synthesis and sodium borohydride reduction of 4-chloro- (1) and 4-unsubstituted- (3) 5,6,7,8-tetrahydrobenzothienopyrimidines, substituted with various groups, such as chloro, hydrogen, methyl, phenyl, amino, ethoxy, methylthio, methylsulfin
Synthesis and Biological Activity of Tetrazolothienopyrimidines
Shishoo, C. J.,Devani, M. B.,Karvekar, M. D.,Ullas, G. V.,Ananthan, S.,et al.
, p. 666 - 668 (2007/10/02)
4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.
