35149-32-7Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
Elmenier, Fatma M.,Lasheen, Deena S.,Abouzid, Khaled A. M.
, p. 315 - 332 (2022/01/04)
Cancer is one of the most aggressive diseases characterised by abnormal growth and uncontrolled cell division. PI3K is a lipid kinase involved in cancer progression which makes it fruitful target for cancer control. 28 new morpholine based thieno[2,3-d] p
Synthesis of some new tetrahydrobenzo[b] thiophene derivatives and tetrahydrobenzo-thienopyrimidine derivatives under microwave irradiation
Abdalha,El-Kassaby, M.K. Abou,El-Regal,Ali
, p. 2811 - 2821 (2011/09/12)
2-Phenyl-5,6,7,8-tetrahydro-4H-benzothieno[2,3-d][1,3]oxazin-4-one (4) was reacted with either aliphatic or aromatic primary amines such as benzylamine, cyclohexylamine, p-toluidine, and=or p-anisidine to give carboxamide derivatives 5a-d, respectively. A
Multistep, microwave assisted, solvent free synthesis and antibacterial activity of 6-substituted-2,3,4-trihydropyrimido[1,2-c]9,10,11,12- tetrahydrobenzo[b]thieno[3,2-e]pyrimidines
Raghu Prasad, Mailavaram,Pran Kishore, Deb
, p. 776 - 779 (2008/02/08)
A novel, efficient, microwave assisted route for the synthesis of 6-substituted-2,3,4-trihydropyrimido[1,2-c]-9,10,11,12-tetrahydrobenzo[b] thieno[3,2-e]pyrimidines in good yields has been developed. The intermediates, 2-substituted-4-[3-hydroxy(propyl-1-
Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines
Prasad, Mailavaram Raghu,Rao, Akkinepalli Raghu Ram,Rao, Pamulaparthi Shanthan,Rajan, Kombu Subramanian
, p. 2119 - 2123 (2007/10/03)
A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.
Synthesis and Biological Activity of Tetrazolothienopyrimidines
Shishoo, C. J.,Devani, M. B.,Karvekar, M. D.,Ullas, G. V.,Ananthan, S.,et al.
, p. 666 - 668 (2007/10/02)
4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.
3,4-Dihydrothienopyrimidines. II. Synthesis and Sodium Borohydride Reduction of 2-Substituted 4-Chloro- and 4-Unsubstituted-thienopyrimidines
Yamaguchi, Hitoshi,Ishikawa, Fumiyoshi
, p. 326 - 332 (2007/10/02)
The synthesis and sodium borohydride reduction of 4-chloro- (1) and 4-unsubstituted- (3) 5,6,7,8-tetrahydrobenzothienopyrimidines, substituted with various groups, such as chloro, hydrogen, methyl, phenyl, amino, ethoxy, methylthio, methylsulfin
