52535-73-6

Basic information

• Product Name: 2-(BENZOYLAMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLIC ACID
• Synonyms: 2-benzamido-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid;2-[(phenylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
• CAS NO: 52535-73-6
• Molecular Formula: C₁₆H₁₅NO₃S
• Molecular Weight: 301.36
• Mol File: 52535-73-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(BENZOYLAMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BENZOYLAMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLIC ACID(52535-73-6)
• EPA Substance Registry System: 2-(BENZOYLAMINO)-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLIC ACID(52535-73-6)

Safety Data

• Hazardous Substances Data: 52535-73-6(Hazardous Substances Data)

Usage

General Description

2-(Benzoylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid is a synthetic compound with potential antitumor and cancer chemopreventive activities. This chemical is a member of the benzothiophene carboxylic acid family and has shown promising results in inhibiting the growth of various cancer cells, including breast, prostate, and colon cancer. It works by targeting specific pathways involved in cancer progression, such as cell proliferation and apoptosis, making it a potential candidate for the development of new anticancer drugs. Additionally, research has shown that this compound also exhibits anti-inflammatory properties, which can further contribute to its potential therapeutic applications.

Upstream product

• 52580-57-1 2-benzamide-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 5936-58-3 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 
• 108-94-1 cyclohexanone 

Downstream Products

• 51948-22-2 4,5-Tetramethylene-2-benzoylaminothiophene 
• 73696-35-2 5,6,7,8-tetrahydro-2-phenyl-4H-benzo<4,5->thieno<2,3-d><3,1>-oxazin-4-one 
• 73696-42-1 2-benzamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbohydrazide 
• 52535-80-5 N-(3-phenylazo-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-benzamide 
• 52535-86-1 N-(3-Dibutylaminomethyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-benzamide 
• 301321-81-3 C₂₀H₂₄N₂O₂S 
• 63274-59-9 2-phenyl-5,6,7,8-tetrahydro-4H-benzothieno[2,3-d][1,3]thiazin-4-one 
• 35149-36-1 2-phenyl-4-methoxy-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine 
• 35149-32-7 4-chloro-2-phenyl-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine 
• 455898-84-7 2-benzamido-N-benzyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 296770-68-8 2-benzamido-N-cyclohexyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 328278-79-1 2-benzamido-N-(4-methoxylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 356586-88-4 N-[3-(piperidine-1-carbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-yl]benzamide 
• 312948-88-2 C₂₀H₂₂N₂O₃S 

Relevant articles and documents

Preparation method and application of tetrahydrobenzothiophene compound and pharmaceutical composition

The invention belongs to the field of medicines, and particularly relates to a tetrahydrobenzothiophene compound as well as a pharmaceutical composition and a preparation method and application thereof. The tetrahydrobenzothiophene compound is a compound I as shown I. In-flight R1 And R2 The C1 -4 is a saturated/unsaturated hydrocarbon group. - OCH3 , OCH2 CH3 Phenyl, substituted phenyl, NO2 One - COR of - OH - F, Cl - Br. I - H R1 AND R2 Or different. R3 It is-F. - Cl, Br, I, OH, Amino, C1 -4 saturated/unsaturated hydrocarbon group, OCH3 , OCH2 CH3 , H, Wherein one of them is, n ≥ 5, n Being an integer. The compound effectively inhibits salmonella by inhibiting the synthesis of ATP-dependent transporter in the lipopolysaccharide synthesis pathway. Aeruginosa, escherichia coli and staphylococcus aureus.

Synthesis of some new tetrahydrobenzo[b] thiophene derivatives and tetrahydrobenzo-thienopyrimidine derivatives under microwave irradiation

2-Phenyl-5,6,7,8-tetrahydro-4H-benzothieno[2,3-d][1,3]oxazin-4-one (4) was reacted with either aliphatic or aromatic primary amines such as benzylamine, cyclohexylamine, p-toluidine, and=or p-anisidine to give carboxamide derivatives 5a-d, respectively. A