35162-01-7

Upstream product

• 38926-88-4 1,2,3-tribromo-4-(2,4-dibromophenoxy)-5-methoxybenzene 
• 19393-94-3 2,4-dibromo-1-iodo-benzene 
• 615-57-6 2,4-dibromo-aniline 
• 90-05-1 2-methoxy-phenol 
• 38926-85-1 2-Methoxy-4,5,6-tribromophenol 

Downstream Products

• 38926-88-4 1,2,3-tribromo-4-(2,4-dibromophenoxy)-5-methoxybenzene 
• 1695-04-1 2-methoxyphenyl phenyl ether 

Relevant academic research and scientific papers

Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium

Bromoiesol sulfates A (1) and B (2), new polyhalogenated aryl sulfates, were isolated from a Salileptolyngbya sp. marine cyanobacterium along with their hydrolyzed compounds, bromoiesols A (3) and B (4). To pick up the candidates of their structures, we u

Antibacterial compounds and uses thereof

The invention relates to antibacterial compounds and their use to treat bacterial infections. More particularly, the invention relates to substituted biphenyl compounds having antibacterial activity. The invention provides methods for treating bacterial infections using PBDEs that have not previously been used to treat bacterial infections. The invention further provides novel PBDEs that are useful in such methods.

Synthesis of hydroxylated and methoxylated polybrominated diphenyl ethers - Natural products and potential polybrominated diphenyl ether metabolites

Hydroxylated and methoxylated polybrominated diphenyl ethers (OH-PBDEs and MeO-PBDEs) may be natural products or they may be formed as metabolites of polybrominated diphenyl ethers (PBDEs), frequently used as flame retardants. The aim of this work was to synthesize authentic OH- and MeO-PBDE reference standards for analytical and toxicological studies. Brominated phenoxybenzaldehydes were prepared either by coupling of 2,4-dibromophenol with various fluorobenzaldehydes or by coupling of brominated hydroxybenzaldehydes with 2,2′,4,4′-tetrabromodiphenyliodonium chloride. OH-PBDEs were synthesized via the brominated phenoxybenzaldehydes by Baeyer-Villiger oxidation and acid-catalyzed hydrolysis. These OH-PBDEs were ortho- and para-brominated (relative to the hydroxy group) with benzyltrimethylammonium tribromide and/or orthobrominated with bromine/tert-butylamine, and were also brominated with bromine in one case. MeO-PBDEs were obtained by methylation of the prepared OH-PBDEs. MeO-PBDEs were also prepared through the coupling of brominated methoxyphenols with 2,2′,4,4′-tetrabromodiphenyliodonium salts, the corresponding OH-PBDEs being obtained after demethylation. A majority of the OH-/MeO-PBDEs prepared have the hydroxy/methoxy group in the ortho position relative to the diphenyl ether bond. All OH-/MeO-PBDEs prepared have 2,4-dibromo substitution patterns (relative to the diphenyl ether bond) in the non-hydroxy-/non-methoxy-containing ring. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

SYNTHESIS OF POLYBROMINATED DIPHENYL ETHERS OF MARINE ORIGIN

Polybrominated diphenyl ethers - antimicrobial metabolites of the marine sponge Dysidea fragilis - have been obtained by the reaction of 2,3,5-tribromonitrobenzene with 3,5-dibromo-2-methoxyphenol and the reaction of brominated diphenyliodonium salts with

Synthesis of Some Polybrominated Diphenyl Ethers Found in Marine Sponges

A simple general route for the synthesis of polybrominated diphenyl ethers is reported.