35173-70-7

Upstream product

• 10511-51-0 1-Benzylindole-3-carboxaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 3377-71-7 N-benzylindole 
• 1137-96-8 N-(benzylidene)aniline N-oxide 
• 100-52-7 benzaldehyde 
• 120-72-9 indole 
• 39487-54-2 1-((dimethylamino)(phenyl)methyl)naphthalen-2-ol 
• 100-46-9 benzylamine 
• 261637-58-5 (1-benzyl-1H-indol-3-yl)(phenyl)methanol 

Downstream Products

• 256391-56-7 1-(1-benzyl-1H-indol-3-yl)-2,2,2-trifluoroethan-1-one 

Relevant academic research and scientific papers

A facile iron-catalyzed dual C-C bond cleavage: An approach towards triarylmethanes

A facile iron-catalyzed dual C-C bond cleaving reaction involving 1,3-dicarbonyl units along with electron-rich and sterically bulky arenes as efficient carbon-based leaving groups has been developed. The scope of the dual C-C bond breaking reaction was s

Sulfonated Tetraphenylethylene-Based Hypercrosslinked Polymer as a Heterogeneous Catalyst for the Synthesis of Symmetrical Triarylmethanes via a Dual C-C Bond-Cleaving Path

A sulfonic acid functionalized tetraphenylethylene-based hypercrosslinked polymer (THP-SO 3H) with a well-developed porous network and accessible sulfonic acid sites was synthesized and characterized by different analytical techniques. The cata

Visible-light-mediated anti-regioselective nitrone 1, 3-dipolar cycloaddition reaction and synthesis of bisindolylmethanes

The development of photoredox reactions of 1, 3- dipolar cycloaddition of nitrones with alkenes is reported. It offers an efficient synthetic method to obtain isoxazolidine derivatives under mild conditions in synthetically useful yields. The nitrones are cyclized with oxidizable styrenes and aliphatic alkenes via a polar radical crossover cycloaddition reaction through photocatalytic reaction without additives. In addition, bis(indole)methanes can also be prepared through this method.

Poly-substituted bis-indolymethane derivative and preparation method thereof

The invention relates to a poly-substituted bis-indolymethane derivative and a preparation method thereof. The structural formula of the derivative is as shown in a formula (I) in the specification, R refers to substituted aryl or alkyl, R refers to alkoxy, halogen or alkyl, the substituted aryl comprises phenyl and naphthyl, and the alkyl comprises methyl, ethyl and cyclohexyl. The preparation method includes the steps: dissolving a nitrone derivative as shown in a formula (II), an indole structure compound as shown in a formula (III) and a photocatalyst as shown in a formula (IV) in an organic solvent under nitrogen atmosphere at room temperature; uniformly mixing the materials; illuminating mixture under blue LEDs (light-emitting diodes) lamps (or other visible light sources such as incandescent lamps) for a few hours; performing rotary evaporation on the solvent after complete reaction; performing chromatographic separation and purification by a silica gel column to obtain the poly-substituted bis-indolymethane derivative. The preparation method solves the problems that an existing bis-indolymethane derivative needs a transitional metal catalysis system in synthesis, yield is low, and an existing method is poor in environmental protection property. Reaction conditions are mild, the method is simple, operation is convenient, and yield is high.

Exploration of Aberrant Behaviour of Grignard Reagents with Indole-3-carboxaldehyde: Application to the Synthesis of Turbomycin B and Vibrindole A Derivatives

An aberrant reaction of Grignard reagents with N-alkylated indole-3-carboxaldehyde has been observed. Contrary to the usual formation of an alcohol, it afforded an unusual bis(indolyl)methane product. A systematic study on this new mode of reactivity and its application to a synthesis of the potent antibiotic turbomycin B and vibrindole A derivatives is reported.

Br?nsted-Acid-Mediated Divergent Reactions of Betti Bases with Indoles: An Approach to Chromeno[2,3-b]indoles through Intramolecular Dehydrogenative C2-Alkoxylation of Indole

Divergent reactions of various 1-(aminoalkyl)naphthols and 2-(aminoalkyl)phenols (commonly known as Betti bases) with indoles under Br?nsted acid catalysis is reported. With the reaction strategies, one can efficiently synthesize important indole derivatives such as 3-(α,α-diarylmethyl)indoles and chromeno[2,3-b]indoles. Furthermore, we disclose here a new C–C bond-cleavage reaction, in which naphthol and phenol behave as leaving groups to produce diarylmethanes. Inexpensive reagents such as p-toluenesulfonic acid monohydrate and molecular iodine are used to catalyze the reactions. No metal catalyst is required. The starting material of the reactions, Betti bases, are easily prepared from a three-component reaction of naphthol/phenol, aldehydes, and secondary amines. The mechanisms for the reactions are established through some control experiments. Quinone methide is the key intermediate for all the reactions reported herein.

Iron-catalyzed oxidative coupling of benzylamines and indoles: Novel approach for synthesis of bis(indolyl)methanes

A novel route for synthesis of bis(indolyl)methanes has been developed by the oxidative coupling of benzylamines and indoles in the presence of iron(II) triflate as a catalyst and molecular oxygen as an oxidant. This method promises versatility, cost-effectiveness, and efficiency.

Synthesis of trifluoromethylindolocarbazoles, novel cyclic 18-membered and 27-membered N-arylmethyldi- and triindoles and an N-arylmethyltetraindolyltrimethane

5,11-Dihydro-5,11-diarylmethyl-6-trifluoromethylindolo[3,2-b]carbazoles (3b-d) have been synthesised from both N-arylmethylindole-3-carbinols (1b-d) and N,N′-diarylmethyl-3,3′-diindolylmethanes (2b, c and f) by treatment with trifluoroacetic anhydride. The cyclic N-arylmethylindoledi- and trimers (4c-f) and the 3-trifluoroacetylindoles (5a and b) have also been obtained from this reaction. Thermal reaction of 1b-d furnishes 2b, c and f, but 1c also affords the N-arylmethyltriindolyldimethane (2d) and the N-arylmethyltetraindolyltrimethane (2e). The results are discussed and the plausible reaction mechanism is very briefly presented.