3518-85-2

Basic information

• Product Name: methyl 3-(2-methoxycarbonylethylamino)propanoate
• Synonyms: methyl 3-(2-methoxycarbonylethylamino)propanoate
• CAS NO: 3518-85-2
• Molecular Formula: C₈H₁₅NO₄
• Molecular Weight: 189.21
• Mol File: 3518-85-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 7-8 °C
• Boiling Point: 257.4°Cat760mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.072g/cm³
• PKA: 7.65±0.19(Predicted)
• CAS DataBase Reference: methyl 3-(2-methoxycarbonylethylamino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(2-methoxycarbonylethylamino)propanoate(3518-85-2)
• EPA Substance Registry System: methyl 3-(2-methoxycarbonylethylamino)propanoate(3518-85-2)

Safety Data

• Hazardous Substances Data: 3518-85-2(Hazardous Substances Data)

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 7664-41-7 ammonia 
• 793-19-1 bis(2-methoxycarbonylethyl)benzylamine 
• 3395-91-3 Methyl 3-bromopropionate 
• 4138-35-6 methyl 3-aminopropanoate 
• 67363-88-6 methyl 3-((2-(methoxycarbonyl)ethyl)amino)propanoate hydrochloride 

Downstream Products

• 14002-33-6 bis-(3-hydroxypropyl)amine 
• 1331741-05-9 C₁₆H₂₄N₃O₁₁P 
• 13221-89-1 1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 34737-83-2 1-methylpiperidin-4-one hydrochloride 
• 1448821-85-9 C₃₆H₃₄N₂O₈ 
• 75403-52-0 C₂₂H₂₈N₃O₂P 
• 75403-51-9 2,10-dimethyl-2,6,10-triaza-1-phosphabicyclo<4.4.0>decane 
• 74378-80-6 2,10-dioxa-6-aza-1-phosphabicyclo<4.4.0>decane 
• 182002-25-1 3-[(2-Benzyloxycarbonylamino-acetyl)-(2-carboxy-ethyl)-amino]-propionic acid 
• 883700-27-4 N,N-bis[2-(2-aminoethylcarbamoyl)-ethyl]-4-iodobenzamide 
• 62737-40-0 N,N-Bis-(2-methoxycarbonyl-ethyl)-benzamid 

Relevant articles and documents

AB2-type amphiphilic block copolymer containing a pH-cleavable hydrazone linkage for targeted antibiotic delivery

A novel AB2-type amphiphilic block copolymer [OA-C[dbnd]N-NH-(PEG)2] with hydrazone linkage was synthesized and explored for pH-triggered antibiotic delivery. Vancomycin (VCM) loaded micelles of the polymer [OA-C[dbnd]N-NH-(PEG)2-VCM] were spherical in shape with size, polydispersity index, zeta potential and entrapment efficiency of 130.33 ± 7.36 nm, 0.163 ± 0.009, ?4.33 ± 0.55 mV and 39.61 ± 4.01% respectively. The dilution stability study exhibited no significant change in the size distribution of OA-C[dbnd]N-NH-(PEG)2-VCM micelles up to 320-fold dilution. An in vitro drug release assay confirmed greater release of VCM from OA-C[dbnd]N-NH-(PEG)2-VCM at pH 6, compared to pH 7.4. An in vitro antibacterial activity evaluation of OA-C[dbnd]N-NH-(PEG)2-VCM showed 2-fold enhancement in antibacterial activity of VCM after 54 h of incubation against Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA) at acidic pH compared to physiological pH. An in vivo antibacterial activity of OA-C[dbnd]N-NH-(PEG)2-VCM further proved the enhanced activity of OA-C[dbnd]N-NH-(PEG)2-VCM against MRSA. In conclusion, micelles from pH-responsive OA-C[dbnd]N-NH-(PEG)2 could be utilized for site-specific delivery of VCM at the infection site.

RECYCLABLE CATALYSTS FOR CHLORINATION OF ORGANIC ACIDS AND ALCOHOLS

The present invention discloses recyclable polymeric catalyst of Formula I, for chlorination of organic acids and alcohols using chlorinating agents such as carbonyl chloride, oxalyl chloride or thionyl chloride, wherein, ‘m’ on the pendent groups on polystyrene backbone can have values from 1 to 5 and R is the alkyl group ranging from C1 to C5.

Parent-amido (NH2) palladium(II) complexes: Synthesis, reactions, and catalytic hydroamination

The treatment of [PdL3(NH3)](OTf)n (n = 1; L3 = (PEt3)2(Ph), (2,6-(Cy2PCH2)2C6H3), n = 2; L3 = (dppe)(NH3)) with NaNH2 in tetrahydrofuran at ambient temperature or -78 °C afforded the dimeric and monomeric parent-amido palladium(II) complexes anti-[Pd(PEt3)(Ph)(μ-NH2)]2 (1), [Pd(dppe)(μ-NH2)]2(OTf)2 (2), and Pd(2,6-(Cy2PCH2)2C6H3)(NH2) (3), respectively. The molecular structures of the amido-bridged (μ-NH2) dimeric complexes 1 and 2 were determined by single-crystal X-ray crystallography. The monomeric amido complex 3 reacted with trace amounts of water to give a hydroxo complex, Pd(2,6-(Cy2PCH2)2C6H3)(OH) (4). Exposing complex 3 to an excess of water resulted in the complete conversion of the complex into two species [Pd(2,6-(Cy2PCH2)2C6H3)(OH2)]+ and [Pd(2,6-(Cy2PCH2)2C6H3)(NH3)]+. Complex 3 reacted with diphenyliodonium triflate ([Ph2I]OTf) to give the aniline complex [Pd(2,6-(Cy2PCH2)2C6H3)(NH2Ph)]OTf. The reaction of 3 with phenylacetylene (HCCPh) yielded a palladium(II) acetylenide Pd(2,6-(Cy2PCH2)2C6H3)(CCPh) (5), quantitatively, along with the liberation of ammonia. The reaction of 3 with dialkyl acetylenedicarboxylate yielded diastereospecific palladium(II) vinyl derivatives (Z)-Pd(2,6-(Cy2PCH2)2C6H3)(CRCR(NH2)) (R = CO2Me (6a), CO2Et (6b)). The reaction of complexes 6a and 6b with p-nitrophenol produced Pd(2,6-(Cy2PCH2)2C6H3)(OC6H4-p-NO2) (7) and cis-CHRCR(NH2), exclusively. Reactions of 3 with either dialkyl maleate (cis-(CO2R)CHCH(CO2R)) (R = CH3, CH2CH3) or cis-stilbene (cis-CHPhCHPh) did not result in any addition product. Instead, isomerization of the cis-isomers to the trans-isomers occurred in the presence of catalytic amounts of 3. Complex 3 reacted with a stoichiometric amount of acrylonitrile (CH2CHCN) to generate a metastable insertion product, Pd(2,6-(Cy2PCH2)2C6H3)(CH(CN)CH2NH2). On the other hand, the reaction of 3 with an excess of acrylonitrile slowly produced polymeric species of acrylonitrile. The catalytic hydroamination of olefins with NH3 was examined in the presence of Pd(2,6-(Cy2PCH2)2C6H3)(OTf), producing a range of hydroaminated products of primary, secondary, and tertiary amines with different molar ratios of more than 99% overall yield. A mechanistic feature for the observed catalytic hydroamination is described with regard to the aminated derivatives of palladium(II).