351986-85-1 Usage
Uses
Used in Pharmaceutical Industry:
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone serves as a valuable compound for studying the properties and reactivity of triazine derivatives. Its structural features can provide insights into the design and synthesis of new molecules with specific chemical and biological activities.
Used in Material Science:
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone can be utilized in the development of novel materials with specific properties, such as optical, electronic, or magnetic characteristics. Its structural diversity and functional groups can be exploited to create materials with tailored properties for various applications.
Used in Biochemical Applications:
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone may find use in biochemical applications, such as the development of new fluorescent probes, sensors, or imaging agents. Its unique structure and functional groups can be exploited to design molecules with specific interactions with biological targets.
Used in Vacuolin-1 Research:
3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone can be used as a starting material or a structural analog for the development of new compounds with similar or improved biological activities as Vacuolin-1. This could lead to the discovery of new inhibitors for Ca2+-dependent fusion of lysosomes to the cell membrane, potentially impacting the release of lysosomal content and providing new therapeutic strategies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 351986-85-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,9,8 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 351986-85:
(8*3)+(7*5)+(6*1)+(5*9)+(4*8)+(3*6)+(2*8)+(1*5)=181
181 % 10 = 1
So 351986-85-1 is a valid CAS Registry Number.
351986-85-1Relevant academic research and scientific papers
Chen, Chang,Lu, Yingying,Siu, Ho Ming,Guan, Jintao,Zhu, Longchao,Zhang, Shuang,Yue, Jianbo,Zhang, Liangren
, (2017)
Autophagy is a fundamental cellular degradation process which is essential for cell homeostasis, and dysfunctional autophagy has been associated with a variety of human diseases, such as cancer. Several autophagy chemical modulators have been applied in a number of preclinical or clinical trials against these autophagy related diseases, especially cancer. Small molecule vacuolin-1 potently and reversibly inhibits both endosomal-lysosomal trafficking and autophagosome-lysosome fusion, yet the molecular mechanisms underlying vacuolin-1 mediated autophagy inhibition remain unknown. Here, we first performed the virtual drug screening and identified 14 vacuolin-1 analogues as autophagy inhibitors. Based on these virtual screening results, we further designed and synthesized 17 vacuolin-1 analogues, and found that 13 of them are autophagy inhibitors and a couple of them are as potent as vacuolin-1. In summary, these studies expanded the pool of useful autophagy inhibitors and reveal the structural-activity relationship of vacuolin-1 analogues, which is useful for future development of vacuolin-1 analogues with high potency and for identification of the molecular targets of vacuolin-1.
