16033-74-2

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 122-39-4 diphenylamine 

Downstream Products

• 1049678-69-4 4-(2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)ethoxy)-6-chloro-N,N-diphenyl-1,3,5-triazin-2-amine 
• 1155375-67-9 4-(2-(6-(5-methylpyridin-2-yl)pyridin-3-yl)ethoxy)-6-chloro-N,N-diphenyl-1,3,5-triazin-2-amine 
• 1155375-66-8 4-(2-(5-(4-methylpyridin-2-yl)pyridin-3-yl)ethoxy)-6-chloro-N,N-diphenyl-1,3,5-triazin-2-amine 
• 1155375-68-0 4-(2-(6-(pyridin-2-yl)pyridin-2-yl)ethoxy)-6-chloro-N,N-diphenyl-1,3,5-triazin-2-amine 
• 1342315-95-0 4,6-di(9H-carbazol-9-yl)-N,N-diphenyl-1,3,5-triazin-2-amine 
• 1361016-93-4 N₂,N₂-bis(4-bromophenyl)-N₄,N₆-dibutyl-1,3,5-triazine-2,4,6-triamine 
• 1361016-92-3 N₂,N₄-dibutyl-N₆,N₆-diphenyl-1,3,5-triazine-2,4,6-triamine 

Relevant academic research and scientific papers

New triazine bridged triads based on BODIPY-porphyrin systems: Extended absorption, efficient energy transfer and upconverted emission

Two novel triads connecting a BODIPY to ethylenediamine substituted porphyrins via triazine linker have been synthesized and characterized. One of the triads is a linear D-A structure with one BODIPY (D) and one porphyrin (A) bridged by the triazine linke

Synthesis, Spectra, and Theoretical Investigations of 1,3,5-Triazines Compounds as Ultraviolet Rays Absorber Based on Time-Dependent Density Functional Calculations and three-Dimensional Quantitative Structure-Property Relationship

A series of 1,3,5-triazines were synthesized and their UV absorption properties were tested. The computational chemistry methods were used to construct quantitative structure-property relationship (QSPR), which was used to computer aided design of new 1,3,5-triazines ultraviolet rays absorber compounds. The experimental UV absorption data are in good agreement with those predicted data using the Time-dependent density functional theory (TD-DFT) [B3LYP/6–311 + G(d,p)]. A suitable forecasting model (R > 0.8, P 0.0001) was revealed. Predictive three-dimensional quantitative structure-property relationship (3D-QSPR) model was established using multifit molecular alignment rule of Sybyl program, which conclusion is consistent with the TD-DFT calculation. The exceptional photostability mechanism of such ultraviolet rays absorber compounds was studied and confirmed as principally banked upon their ability to undergo excited-state deactivation via an ultrafast excited-state proton transfer (ESIPT). The intramolecular hydrogen bond (IMHB) of 1,3,5-triazines compounds is the basis for the excited state proton transfer, which was explored by IR spectroscopy, UV spectra, structural and energetic aspects of different conformers and frontier molecular orbitals analysis.

Organic compound taking triazine and benzimidazole as cores and application thereof

The invention relates to an organic compound taking triazine and benzimidazole as cores and application thereof to an OLED (Organic Light Emitting Diode) device. The compound provided by the invention has relatively high glass transition temperature and m

A triazine and quinoxaline as the core of the organic compound and its application on the OLED (by machine translation)

The invention relates to a triazine and quinoxaline as the core of the organic compound and its application on the OLED device, compounds of the invention have higher glass transition temperature and molecular thermal stability; and low absorption in the

Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives

A series of 4-anilinoquinoline triazine derivatives were designed, synthesized and screened for in vivo antimalarial activity against a chloroquine-sensitive strain of Plasmodium berghei. The compounds were further subjected to in vitro antimalarial activity against chloroquine-resistant W2 strain of Plasmodium falciparum and β-haematin inhibition studies. All the compounds exhibited in vivo antimalarial activity better than that shown by the standard drug, chloroquine. Twelve out of fifteen compounds showed better inhibition than that of chloroquine against chloroquine-resistant W2 strain of Plasmodium falciparum. Ten compounds showed β-haematin inhibition, better than that of chloroquine, with IC50 values in the range of 18–25?μM. One compound, 3k, was found to be better than artemisinin against W2 strain of Plasmodium falciparum and also displayed the best β-haematin inhibitory activity, thereby becoming eligible to be explored as a potential lead for antimalarial chemotherapy.

Identification of novel vacuolin-1 analogues as autophagy inhibitors by virtual drug screening and chemical synthesis

Autophagy is a fundamental cellular degradation process which is essential for cell homeostasis, and dysfunctional autophagy has been associated with a variety of human diseases, such as cancer. Several autophagy chemical modulators have been applied in a number of preclinical or clinical trials against these autophagy related diseases, especially cancer. Small molecule vacuolin-1 potently and reversibly inhibits both endosomal-lysosomal trafficking and autophagosome-lysosome fusion, yet the molecular mechanisms underlying vacuolin-1 mediated autophagy inhibition remain unknown. Here, we first performed the virtual drug screening and identified 14 vacuolin-1 analogues as autophagy inhibitors. Based on these virtual screening results, we further designed and synthesized 17 vacuolin-1 analogues, and found that 13 of them are autophagy inhibitors and a couple of them are as potent as vacuolin-1. In summary, these studies expanded the pool of useful autophagy inhibitors and reveal the structural-activity relationship of vacuolin-1 analogues, which is useful for future development of vacuolin-1 analogues with high potency and for identification of the molecular targets of vacuolin-1.

Sigma-spacer regulated thiophenyl triazine conjugates: Synthesis and crystal, electronic and luminescent properties

A water-accelerated Pd catalyzed Suzuki-Miyaura cross-coupling reaction was developed for the synthesis of thiophenyl triazine conjugates (TTCs). The compounds (2a-2e and 3a-3e) with five σ-spacers were obtained and fully characterized. The X-ray analysis of 2a, 2d, and 3d found that the length of the intermolecular H bond was 3.465(3) ? and the π-π interactions ranged from 3.6538(2)-3.9519(1) ?. Five σ-spacers of TTCs had an effect on their emissions from blue (363 nm) to yellow (530 nm) whilst 2- and 3-thiophenyl chromophores finely tune the emission from 530 to 504 nm. The DFT computation showed the TTCs had low HOMO (-6.8 eV) and LUMO (-2.5 eV) energy and high triplet energy (ET, 2.4 eV). The energy level and gap of TTCs were regularly modulated by the σ-spacer.

Bistriazine-based streptocyanines. Preparation, structural determination and optoelectronic properties

A series of bistriazine-based streptocyanines has been selectively prepared. A variety of substituents has been introduced into the triazine ring with p-phenylenediamine as a conjugated spacer between the triazine and the streptocyanine moieties. Fukui in

Synthesis and applications of a novel supramolecular polymer network with multiple H-bonded melamine pendants and uracil crosslinkers

A conjugated main-chain copolymer (PBT) consisting of bithiazole, dithieno[3,2-b:2′,3′-d]pyrroles (DTP), and pendent melamine units was synthesized by Stille polymerization, which can be hydrogen-bonded (H-bonded) with proper molar amounts of bi-functiona

Enhancement of photovoltaic properties in supramolecular polymer networks featuring a solar cell main-chain polymer H-bonded with conjugated cross-linkers

Stille polymerization was employed to synthesize a low-band-gap (LBG) conjugated main-chain polymer PBTH consisting of bithiazole, dithieno[3,2-b:2′,3′-d]pyrroles (DTP), and pendent melamine derivatives. Novel supramolecular polymer networks PBTH/C and PBTH/F were developed by mixing proper molar amounts of polymer PBTH (containing melamine pendants) to be hydrogen-bonded (H-bonded) with complementary uracil-based conjugated cross-linkers C and F (i.e., containing two symmetrical uracil moieties connected with carbazole and fluorene units through triple bonds). The formation of multiple H-bonds between polymer PBTH and cross-linkers C or F was confirmed by FT-IR measurements. In contrast to polymer PBTH, the supramolecular design with multiple H-bonds can enhance the photovoltaic properties of polymer solar cell (PSC) devices containing H-bonded polymer networks PBTH/C and PBTH/F by tuning their light harvesting capabilities, HOMO energy levels, and crystallinities. Initially, the power conversion efficiency (PCE) values of PSC devices containing supramolecular polymer networks PBTH/C and PBTH/F as electron donors and [6,6]-phenyl-C71-butyric acid methyl ester (PC 70BM) as an electron acceptor (polymer:PC70BM = 1:1 w/w) are found to be 0.97 and 0.68%, respectively, in contrast to 0.52% for polymer PBTH. The highest PCE value of 1.56% with a short-circuit current densities (Jsc) value of 7.16 mA/cm2, a open circuit voltages (Voc) value of 0.60 V, and a fill factor (FF) of 0.36 was further optimized in the PSC device containing a supramolecular polymer network PBTH/C as polymer:PC70BM = 1:2 w/w. These results indicate that supramolecular design is an effective route towards better photovoltaic properties of Voc, Jsc, and PCE values in polymer solar cells.