35207-71-7

Basic information

• Product Name: 3-CHLOROCYCLOBUTANECARBOXYLIC ACID
• Synonyms: 3-CHLOROCYCLOBUTANECARBOXYLIC ACID;Cyclobutanecarboxylic acid, 3-chloro-;3-chlorocyclobutane-1-carboxylic acid
• CAS NO: 35207-71-7
• Molecular Formula: C₅H₇ClO₂
• Molecular Weight: 134.56
• Mol File: 35207-71-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 253℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.34
• Vapor Pressure: 0.00568mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLOROCYCLOBUTANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROCYCLOBUTANECARBOXYLIC ACID(35207-71-7)
• EPA Substance Registry System: 3-CHLOROCYCLOBUTANECARBOXYLIC ACID(35207-71-7)

Safety Data

• Hazardous Substances Data: 35207-71-7(Hazardous Substances Data)

Usage

General Description

3-Chlorocyclobutanecarboxylic acid is a chemical compound containing chlorine, which belongs to the family of cyclobutanes. As an organic compound, it has acidic properties due to the carboxylic acid group in its molecular structure. Its chemical formula is C5H7ClO2, displaying that it also comprises carbon, hydrogen, and oxygen elements. The molecular weight of this compound is approximately 136.56 g/mol. Currently, there is limited information regarding the specific applications, hazards, or toxicities related to this compound, due to it being relatively less common or less studied that many other chemicals. It’s mainly used for chemical and biological research, and largely synthesized in laboratories.

InChI:InChI=1/C5H7ClO2/c6-4-1-3(2-4)5(7)8/h3-4H,1-2H2,(H,7,8)

Upstream product

• 20249-18-7 3-chlorocyclobutanecarbonitrile 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 89582-02-5 3-Chlor-1,1-cyclobutandicarbonsaeure-dichlorid 
• 89639-43-0 3-chlorocyclobutane-1,1-dicarboxylic acid 
• 51816-01-4 cyclobutane-1,1-dicarboxylic acid dichloride 

Downstream Products

• 15963-46-9 3-chlorocyclobutanecarboxylic acid methyl ester 
• 15963-47-0 3-chlorocyclobutanemethanol 
• 74316-27-1 cis-3-aminocyclobutane-1-carboxylic acid 
• 74307-75-8 (1r,3r)-3-aminocyclobutane-1-carboxylic acid 
• 766458-70-2 methyl (1r,3r)-3-aminocyclobutane-1-carboxylate 
• 1212823-38-5 cis-3-aminocyclobutane-1-carboxylic acid methyl ester 
• 4415-82-1 cyclobutanemethanol 
• 1093750-93-6 3-(trifluoromethyl)cyclobutane-1-carboxylic acid 
• 124490-70-6 3-benzyloxymethyl-1-cyclobutene 
• 124490-69-3 [[(3-Chlorocyclobutyl)methoxy]methyl]benzene 

Relevant articles and documents

Interplay of theory and experiment: Reversal of the torquoselectivity of the electrocyclic ring opening of 3-acetylcyclobutene by a Lewis acid

Theoretical predictions, accompanied by firm experimental verification, are presented on the "torquoselectivity" of the thermal ring opening of 3-acetylcyclobutene (1). 3-Acetylcyclobutene was synthesized from commercially available 1,1-cyclobutanedicarboxylic acid. Thermolysis of 3-acetylcyclobutene resulted in a mixture of E- and Z-dienes with a slight preference for the E-diene. This preference was reversed by the Lewis acid, ZnI2, as predicted from theoretical calculations.

Expedient synthesis of cis- and trans-3-aminocyclobutanecarboxylic acids

An expedient approach to cis- and trans-3-aminocyclobutanecarboxylic acids was developed starting from 1,1-cyclobutanedicarboxylic acid. Stereochemistry of the title compounds was established by nuclear Overhauser effect spectroscopy experiments.

SYNTHESIS OF SQ-32,829, A NEW NUCLEOSIDE ANTIVIRAL AGENT

The guanine-containing cyclobutane nucleoside analog SQ-32,829 (1) was synthesized in 8 steps from 1,1-cyclobutanedicarboxylic acid(3).