74316-27-1 Usage
Uses
CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Azide 10a (0.30 g, 1.9 mmol) was dissolved in methanol (5 mL); then 6N HCl (2 mL) and 10% palladium on charcoal were added to the solution. The resulting mixture was stirred under 1 bar of hydrogen for 3 h, then the catalyst was filtered off, and the solvent was removed under reduced pressure. The residue was dissolvedin 6N HCl (5 mL) and refluxed upon stirring for 1 h, then evaporated in vacuum. The residue was purified by ion-exchange chromatography (Amberlite? IR-120(plus) ion-exchange resin, 3.5% aqueous ammonia as an eluent). cis-3-aminocyclobutanecarboxylic acid 1a as white powder, yield 0.16 g, 1.4 mmol, 71%.
Check Digit Verification of cas no
The CAS Registry Mumber 74316-27-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,3,1 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 74316-27:
(7*7)+(6*4)+(5*3)+(4*1)+(3*6)+(2*2)+(1*7)=121
121 % 10 = 1
So 74316-27-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO2/c6-4-1-3(2-4)5(7)8/h3-4H,1-2,6H2,(H,7,8)/t3-,4+
74316-27-1Relevant articles and documents
Expedient synthesis of cis- and trans-3-aminocyclobutanecarboxylic acids
Radchenko, Dmytro S.,Tkachenko, Anton,Grygorenko, Oleksandr O.,Komarov, Igor V.
, p. 1644 - 1649 (2011/06/23)
An expedient approach to cis- and trans-3-aminocyclobutanecarboxylic acids was developed starting from 1,1-cyclobutanedicarboxylic acid. Stereochemistry of the title compounds was established by nuclear Overhauser effect spectroscopy experiments.
