3522-86-9

Usage

Uses

Used in Pharmaceutical Industry:
4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE is utilized as an intermediate in the production of agrochemicals, potentially aiding in the development of compounds that can protect crops and enhance agricultural yields.
Used in Organic Chemistry Research:
4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE is employed as a building block in the preparation of a range of organic compounds, facilitating the advancement of organic chemistry through the creation of novel molecules with potential applications.
Used as a Reagent in Chemical Reactions:
4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE serves as a reagent in various chemical reactions, enabling specific transformations and syntheses that are crucial in the development of new chemical entities and materials.
Used as a Precursor in Chemical Production:
4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE is used as a precursor in the manufacturing process of other chemicals, indicating its importance in the synthesis of a broader array of products in the chemical industry.

Upstream product

• 99-71-8 4-(1-methylpropyl)phenol 
• 121-71-1 3-Hydroxyacetophenone 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 591-20-8 3-Bromophenol 
• 598-30-1 sec.-butyllithium 
• 6565-58-8 1-(2-methylpropyl)-3-methoxybenzene 
• 7446-70-0 aluminium trichloride 
• 10574-17-1 but-2-yl phenyl ether 
• 54932-77-3 2,5-di-(sec-butyl)phenol 
• 108-95-2 phenol 
• 14556-13-9 3,5-di-(sec-butyl)phenol 

Downstream Products

• 60309-21-9 Propyl-carbamic acid 3-sec-butyl-phenyl ester 
• 14556-13-9 3,5-di-(sec-butyl)phenol 
• 108-95-2 phenol 
• 99-71-8 4-(1-methylpropyl)phenol 
• 54932-77-3 2,5-di-(sec-butyl)phenol 
• 60309-22-0 Butyl-carbamic acid 3-sec-butyl-phenyl ester 
• 60309-20-8 Ethyl-carbamic acid 3-sec-butyl-phenyl ester 

Relevant academic research and scientific papers

Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture. Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60 °C) in air, and in competition with protonolysis. Additional benefits include very short reaction times (20 s), good to excellent yields (up to 98 %), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water.

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Scope and limitations of lithium-ethylenediamine-THF-mediated cleavage at the α-position of aromatics: Deprotection of aryl methyl ethers and benzyl ethers under mild conditions

The scope and limitation of lithium-ethylenediamine-THF-mediated reductive bond cleavage at the α-position of aromatics were examined. Very mild conditions such as lithium metal (5 equiv) and ethylenediamine (7 equiv) in oxygen-free THF were quite effective for the demethylation of aromatic ethers even at as low as -10°C. Allyl benzyl ethers were also deprotected under these conditions with very little change of the allylic alcohol moiety. Through this study, 2,6-dimethylbenzyl (m-xylylmethyl, MXM) group was developed as an alternative of benzyl group, which is readily cleavable under the above mentioned reductive conditions.

Equilibria for the isomerization of (secondary-alkyl)phenols and cyclohexylphenols

Equilibria of a series of isomerizations and trans-alkylations of alkylphenols have been investigated in the liquid phase over a wide range of temperatures.Equilibria of isomerizations connected with the displacement of a substituent on a benzene nucleus were studied for secondary-butyl, -amyl, -hexyl, and cyclohexyl-phenols, and di-(secondary-butyl)phenols.Equilibria of positional isomerization connected with the displacement of an oxyphenyl radical in an alkyl chain were investigated for oxyphenyl-pentanes, -hexanes, -octanes, and -decanes.Trans-alkylation was investigated for di- and tri-(secondary-butyl)phenols.Values of ΔrH0m and ΔrS0m were found for all investigated reactions.An analysis was made of the thermodynamic quantities for the reactions.Enthalpies of formation of isopropylphenols (IPP) in the gaseous state were calculated.The values of ΔfH0m/(kJ * mol-1) were found at 298.15 K: o-IPP, -(175.3 +/- 2.4); p-IPP, -(175.3 +/- 2.4); m-IPP, -(175.3 +/-2.4); 2,4-di-IPP, -(254.1 +/- 2.8); 2,5-di-IPP, -(254.1 +/- 2.8); 2,6-di-IPP, -(254.1 +/- 2.8); 3,5-di-IPP, -(254.1 +/- 2.8); 2,4,6-tri-IPP, -(333.0 +/- 3.1).