3522-86-9

Basic information

• Product Name: 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE
• Synonyms: 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE;4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDE;3-sec-Butylphenol;3-butan-2-ylphenol
• CAS NO: 3522-86-9
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 212.67
• Mol File: 3522-86-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 46.81°C (estimate)
• Boiling Point: 236.65°C (estimate)
• Flash Point: 114.4 °C
• Appearance: /
• Density: 0.9688 (estimate)
• Refractive Index: 1.5115 (estimate)
• PKA: 10.04±0.10(Predicted)
• CAS DataBase Reference: 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE(3522-86-9)
• EPA Substance Registry System: 4-TERT-BUTYL-5-CHLORO-2-HYDROXYBENZALDEHYDE(3522-86-9)

Safety Data

• Hazardous Substances Data: 3522-86-9(Hazardous Substances Data)

Usage

General Description

4-tert-butyl-5-chloro-2-hydroxybenzaldehyde is a chemical compound that consists of a benzene ring with a hydroxyl group and a chlorine atom attached to it, along with a tert-butyl group and an aldehyde functional group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical also has potential applications in the field of organic chemistry, such as in the preparation of various organic compounds. Additionally, it may also be used as a reagent in chemical reactions and as a precursor in the production of other chemicals. However, it is important to handle this compound with caution as it may be harmful if it comes into contact with the skin or if inhaled.

Upstream product

• 99-71-8 4-(1-methylpropyl)phenol 
• 14556-13-9 3,5-di-(sec-butyl)phenol 
• 108-95-2 phenol 
• 54932-77-3 2,5-di-(sec-butyl)phenol 
• 7446-70-0 aluminium trichloride 
• 10574-17-1 but-2-yl phenyl ether 
• 6565-58-8 1-(2-methylpropyl)-3-methoxybenzene 
• 591-20-8 3-Bromophenol 
• 598-30-1 sec.-butyllithium 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 14556-13-9 3,5-di-(sec-butyl)phenol 
• 108-95-2 phenol 
• 99-71-8 4-(1-methylpropyl)phenol 
• 54932-77-3 2,5-di-(sec-butyl)phenol 
• 60309-20-8 Ethyl-carbamic acid 3-sec-butyl-phenyl ester 
• 60309-21-9 Propyl-carbamic acid 3-sec-butyl-phenyl ester 
• 60309-22-0 Butyl-carbamic acid 3-sec-butyl-phenyl ester 

Relevant articles and documents

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Scope and limitations of lithium-ethylenediamine-THF-mediated cleavage at the α-position of aromatics: Deprotection of aryl methyl ethers and benzyl ethers under mild conditions

The scope and limitation of lithium-ethylenediamine-THF-mediated reductive bond cleavage at the α-position of aromatics were examined. Very mild conditions such as lithium metal (5 equiv) and ethylenediamine (7 equiv) in oxygen-free THF were quite effective for the demethylation of aromatic ethers even at as low as -10°C. Allyl benzyl ethers were also deprotected under these conditions with very little change of the allylic alcohol moiety. Through this study, 2,6-dimethylbenzyl (m-xylylmethyl, MXM) group was developed as an alternative of benzyl group, which is readily cleavable under the above mentioned reductive conditions.