352292-05-8

Upstream product

• 618914-14-0 5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-3-(2-methyl-allyl)-1H-pyrimidine-2,4-dione 
• 352303-65-2 N-1-(2,6-difluorobenzyl)-6-methyluracil 
• 32923-88-9 3-isobutoxy-1-propylamine 
• 618914-15-1 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-(2-oxo-propyl)-1H-pyrimidine-2,4-dione 
• 618914-13-9 1-(2,6-difluorobenzyl)-3-(3-oxobutyryl)urea 
• 352303-66-3 5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists

The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the β-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best compou