352292-25-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists
Guo, Zhiqiang,Zhu, Yun-Fei,Tucci, Fabio C.,Gao, Yinghong,Struthers, R. Scott,Saunders, John,Gross, Timothy D.,Xie, Qiu,Reinhart, Greg J.,Chen, Chen
, p. 3311 - 3315 (2007/10/03)
The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the β-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best compou
