352293-98-2

Basic information

• Product Name: 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
• CAS NO: 352293-98-2
• Molecular Weight: 506.552
• Mol File: 352293-98-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione(352293-98-2)
• EPA Substance Registry System: 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione(352293-98-2)

Safety Data

• Hazardous Substances Data: 352293-98-2(Hazardous Substances Data)

Upstream product

• 618914-13-9 1-(2,6-difluorobenzyl)-3-(3-oxobutyryl)urea 
• 352303-66-3 5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 
• 352303-65-2 N-1-(2,6-difluorobenzyl)-6-methyluracil 
• 69385-30-4 2,6-difluorobenzylamine 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 618914-15-1 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-(2-oxo-propyl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists

The novel synthesis and SAR studies of 6-methyluracils as human GnRH receptor antagonists are discussed. Introduction of a small methyl substituent at the β-position from N3 of the uracil improved the GnRH binding potency by 5- to 10-fold. The best compou