35234-45-8

Usage

Uses

Used in Pharmaceutical Research:
(E)-2'-Hydroxy-5'-nitrochalcone is used as a compound in pharmaceutical research for its potential biological activities, including anti-inflammatory and antioxidant properties. These characteristics make it a promising candidate for the development of new drugs targeting various health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (E)-2'-Hydroxy-5'-nitrochalcone serves as a valuable intermediate or building block for the creation of more complex molecules with specific applications in various industries.
Used in Dye Industry:
(E)-2'-Hydroxy-5'-nitrochalcone is used as a dye in the dye industry, specifically for its yellow coloring properties. It can be employed in the production of textiles, paints, and other materials requiring vibrant and stable coloration.
Used in Cosmetics:
In the cosmetics industry, (E)-2'-Hydroxy-5'-nitrochalcone may be utilized as a natural coloring agent for various products, such as makeup and hair dyes, due to its yellow hue and potential for safe use in personal care applications.

Upstream product

• 100-02-7 4-nitro-phenol 
• 830-03-5 4-nitrophenol acetate 
• 97-51-8 5-Nitrosalicylaldehyde 
• 637-44-5 phenylpropyolic acid 
• 536-74-3 phenylacetylene 
• 1450-76-6 1-(2-hydroxy-5-nitrophenyl)ethanone 
• 100-52-7 benzaldehyde 

Downstream Products

• 131948-10-2 2'-acetoxy-α-bromo-β-methoxy-5'-nitrodihydrochalcone 
• 131948-11-3 (Z)-5-nitroaurone 
• 131948-12-4 6-Nitroflavone 
• 131948-15-7 2'-acetoxy-5'-nitrochalcone 

Relevant academic research and scientific papers

Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water

A DBU-catalyzed one-pot cascade reaction of propargylamines and water for the synthesis of flavanones has been developed. This process proceeds via a sequence of 1,4-conjugate addition of water to alkynyl o-quinone methide (o-AQM), followed by the alkyne-allene isomerization and subsequent intramolecular oxa-Michael addition. This strategy provides a convenient method for accessing a broad range of flavanones in good to excellent yields with good functional-group tolerance, in particular, the reactive halo functional groups.

Ruthenium-Catalyzed C-H Activation of Salicylaldehyde and Decarboxylative Coupling of Alkynoic Acids for the Selective Synthesis of Homoisoflavonoids and Flavones

Homoisoflavonoids were formed in DMSO exclusively, and flavones were formed in t-AmOH when salicylaldehyde and alkynoic acids reacted with [Ru(p-cymene)Cl2]2 and CsOAc. They were formed through C-H activation of salicylaldehyde and decarboxylative coupling of alkynoic acid. This reaction system showed good yields, broad substrate scope, and good functional group tolerance. It was found that chalcone was an intermediate in the formation of both homoisoflavonoid and flavone.

Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor

A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.