352708-07-7

Basic information

• Product Name: benzylidene-2,2-bis(oxymethyl) propionic anhydride
• Synonyms: benzylidene-2,2-bis(oxymethyl) propionic anhydride
• CAS NO: 352708-07-7
• Molecular Weight: 426.466
• Mol File: 352708-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzylidene-2,2-bis(oxymethyl) propionic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: benzylidene-2,2-bis(oxymethyl) propionic anhydride(352708-07-7)
• EPA Substance Registry System: benzylidene-2,2-bis(oxymethyl) propionic anhydride(352708-07-7)

Safety Data

• Hazardous Substances Data: 352708-07-7(Hazardous Substances Data)

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 207850-04-2 5-methyl-2-phenyl-1,3-dioxane-5-carboxylic acid 

Downstream Products

• 640844-51-5 5-methyl-2-phenyl-[1,3]dioxane-5-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 1611446-29-7 C₄₄H₆₀O₂₀S₉ 
• 1611446-27-5 C₂₄H₃₂O₁₀S₅ 
• 1131064-64-6 TSe-G₂-(OH)4 
• 1131064-62-4 TSe-G₂-(O₂Bn)2 
• 1131064-60-2 TSe-G₁-(OH)2 
• 1446499-70-2 C₄₂H₄₂O₁₂ 
• 1451737-65-7 C₃₁H₃₀O₁₀ 
• 208581-60-6 C₄-([G-1]Ph)4 
• 1304771-43-4 C₃-([G-1]Ph)3 
• 1131064-56-6 TSe-G₁-(O₂Bn) 
• 1131064-65-7 TSe-G₃-(O₂Bn)4 
• 1067926-76-4 8-(3-acetylphenyl)-3',5'-bis-O-(5-methyl-2-phenyl-1,3-dioxane-5-carbonyl)-2'-deoxyguanosine 
• 199457-36-8 3-hydroxy-2-hydroxymethyl-2-methyl-propionic acid 4-{1,1-bis-[4-(3-hydroxy-2-hydroxymethyl-2-methyl-propionyloxy)-phenyl]-ethyl}-phenyl ester 

Relevant articles and documents

Tumor-Targeting Micelles Based on Linear-Dendritic PEG-PTX8 Conjugate for Triple Negative Breast Cancer Therapy

Most small molecular chemotherapeutics have poor water solubility and unexpected pharmacokinetics and toxicity to normal tissues. A series of nano drug delivery systems have been developed to solve the problems, among which a micelle based on linear-dendritic polymer-drug conjugates (LDPDCs) is a promising strategy to deliver hydrophobic chemotherapeutics due to its small size, fine stability in blood circulation, and high drug loading capacity. In this work we synthesized a novel amphiphilic linear-dendritic PEG-PTX8 conjugate which can also encapsulate extra free PTX and self-assemble into uniform ultrasmall micelles with a hydrated diameter of 25.50 ± 0.27 nm. To realize efficient drug delivery to tumor sites, a cyclic tumor homing and penetrating peptide iNGR was linked to the PEG-PTX8 conjugate. The biological evaluation was performed on a human triple negative breast cancer model. PTX accumulation in tumor at 24 h of the TNBC-bearing mice treated with iNGR-PEG-PTX8/PTX micelles was significantly enhanced (P 8/PTX micelles. Furthermore, iNGR-PEG-PTX8/PTX micelles showed an obvious strong antitumor effect, and the median survival time of TNBC bearing mice treated with iNGR-modified micelles was significantly extended compared to Taxol. Therefore, this smart micelle system may be a favorable platform for effective TNBC therapy.

Fast and convenient divergent synthesis of aliphatic ester dendrimers by anhydride coupling

A novel divergent approach was developed for the synthesis of dendritic aliphatic polyester structures using an acetal-protected anhydride derivative of 2,2-bis(hydroxymethyl)propionic acid as the acylating agent. This divergent synthesis is remarkable, b