352708-07-7

Basic information

• Product Name: benzylidene-2,2-bis(oxymethyl) propionic anhydride
• Synonyms: benzylidene-2,2-bis(oxymethyl) propionic anhydride
• CAS NO: 352708-07-7
• Molecular Weight: 426.466
• Mol File: 352708-07-7.mol

Chemical Properties

• CAS DataBase Reference: benzylidene-2,2-bis(oxymethyl) propionic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: benzylidene-2,2-bis(oxymethyl) propionic anhydride(352708-07-7)
• EPA Substance Registry System: benzylidene-2,2-bis(oxymethyl) propionic anhydride(352708-07-7)

Safety Data

• Hazardous Substances Data: 352708-07-7(Hazardous Substances Data)

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 207850-04-2 5-methyl-2-phenyl-1,3-dioxane-5-carboxylic acid 

Downstream Products

• 1131064-62-4 TSe-G₂-(O₂Bn)2 
• 1131064-65-7 TSe-G₃-(O₂Bn)4 
• 1131064-56-6 TSe-G₁-(O₂Bn) 
• 1611446-29-7 C₄₄H₆₀O₂₀S₉ 
• 1611446-27-5 C₂₄H₃₂O₁₀S₅ 
• 1131064-64-6 TSe-G₂-(OH)4 
• 1131064-60-2 TSe-G₁-(OH)2 
• 1446499-70-2 C₄₂H₄₂O₁₂ 
• 1451737-65-7 C₃₁H₃₀O₁₀ 
• 208581-60-6 C₄-([G-1]Ph)4 
• 1304771-43-4 C₃-([G-1]Ph)3 
• 1067926-76-4 8-(3-acetylphenyl)-3',5'-bis-O-(5-methyl-2-phenyl-1,3-dioxane-5-carbonyl)-2'-deoxyguanosine 
• 640844-34-4 C₆₃H₇₄O₂₂ 
• 199457-36-8 3-hydroxy-2-hydroxymethyl-2-methyl-propionic acid 4-{1,1-bis-[4-(3-hydroxy-2-hydroxymethyl-2-methyl-propionyloxy)-phenyl]-ethyl}-phenyl ester 

Relevant articles and documents

Tumor-Targeting Micelles Based on Linear-Dendritic PEG-PTX8 Conjugate for Triple Negative Breast Cancer Therapy

Most small molecular chemotherapeutics have poor water solubility and unexpected pharmacokinetics and toxicity to normal tissues. A series of nano drug delivery systems have been developed to solve the problems, among which a micelle based on linear-dendritic polymer-drug conjugates (LDPDCs) is a promising strategy to deliver hydrophobic chemotherapeutics due to its small size, fine stability in blood circulation, and high drug loading capacity. In this work we synthesized a novel amphiphilic linear-dendritic PEG-PTX8 conjugate which can also encapsulate extra free PTX and self-assemble into uniform ultrasmall micelles with a hydrated diameter of 25.50 ± 0.27 nm. To realize efficient drug delivery to tumor sites, a cyclic tumor homing and penetrating peptide iNGR was linked to the PEG-PTX8 conjugate. The biological evaluation was performed on a human triple negative breast cancer model. PTX accumulation in tumor at 24 h of the TNBC-bearing mice treated with iNGR-PEG-PTX8/PTX micelles was significantly enhanced (P 8/PTX micelles. Furthermore, iNGR-PEG-PTX8/PTX micelles showed an obvious strong antitumor effect, and the median survival time of TNBC bearing mice treated with iNGR-modified micelles was significantly extended compared to Taxol. Therefore, this smart micelle system may be a favorable platform for effective TNBC therapy.

The first peripherally masked thiol dendrimers: A facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol-acrylate Michael addition reactions

Introducing multiple reactive functional groups at the periphery of dendrimer materials presents considerable challenges if the functionality is able to self-react. An efficient and facile approach to introducing masked thiols at the surface of polyester dendrimers is presented. One-pot, deprotection/thiol-acrylate Michael addition from the xanthate-functional dendritic substrates (generation zero to two) has been achieved for the first time, with high efficiency demonstrated using three acrylates of varying chemistry and avoiding disulfide formation. This journal is the Partner Organisations 2014.

Fast and convenient divergent synthesis of aliphatic ester dendrimers by anhydride coupling

A novel divergent approach was developed for the synthesis of dendritic aliphatic polyester structures using an acetal-protected anhydride derivative of 2,2-bis(hydroxymethyl)propionic acid as the acylating agent. This divergent synthesis is remarkable, b