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2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID is a white crystalline chemical compound with the molecular formula C11H12O4, belonging to the class of dioxane carboxylic acids. It is known for its potential medicinal properties and applications in organic synthesis, although further research is required to fully explore its capabilities.

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  • 207850-04-2 Structure
  • Basic information

    1. Product Name: 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID
    2. Synonyms: 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID
    3. CAS NO:207850-04-2
    4. Molecular Formula: C12H14O4
    5. Molecular Weight: 222.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 207850-04-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID(207850-04-2)
    11. EPA Substance Registry System: 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID(207850-04-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 207850-04-2(Hazardous Substances Data)

207850-04-2 Usage

Uses

Used in Pharmaceutical Industry:
2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID is used as a central nervous system stimulant for its potential medicinal properties, contributing to the development of treatments for various conditions related to CNS disorders.
Used in Organic Synthesis:
In the field of organic synthesis, 2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID serves as a valuable intermediate or building block for the synthesis of more complex organic compounds, facilitating the creation of novel pharmaceuticals and other specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 207850-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,8,5 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 207850-04:
(8*2)+(7*0)+(6*7)+(5*8)+(4*5)+(3*0)+(2*0)+(1*4)=122
122 % 10 = 2
So 207850-04-2 is a valid CAS Registry Number.

207850-04-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methyl-2-phenyl-1,3-dioxane-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names 5-methyl-2-phenyl-1,3-dioxinane-5-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:207850-04-2 SDS

207850-04-2Relevant articles and documents

Dendrimer-like star polymers

Trolls?s, Mikael,Hedrick, James L.

, p. 4644 - 4651 (1998)

Dendrimer-like star polymers, a novel type of molecular architecture, have been synthesized. The architecture of the new polymers resembles that of three-dimensional spherical dendrimers as well as classical star polymers. The controlled structures, based

Synthesis and characterization of linear, homopolyester, benzoyl-protected Bis-MPA

Kareem, Oluwapelumi O.,Daymon, Samantha P.,Keller, Christopher B.,Chen, Beibei,Nazarenko, Sergei,Grayson, Scott M.

, p. 6608 - 6618 (2020)

Because of the growing interest in bis-MPA dendrimers and hyperbranched polymers, a linear, polyester equivalent is of great importance in understanding how this commercially viable family of branched polymers behaves when compared to their linear analogs

Non-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides

Brzezinska, Jolanta,Markiewicz, Wojciech T.

, p. 12652 - 12669 (2015)

The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogues built from units that carry different diol structures instead of sugar residues and functionalized with polyamines. The non-nucleosidic analogues were attached as internal or 5′-terminal modifications in oligodeoxyribonucleotide strands. The thermodynamic studies of these polyaminooligonucleotide analogues revealed stabilizing or destabilizing effects that depend on the linker or polyamine used.

Tumor-Targeting Micelles Based on Linear-Dendritic PEG-PTX8 Conjugate for Triple Negative Breast Cancer Therapy

Zhang, Yujie,Lu, Yifei,Zhang, Yu,He, Xi,Chen, Qinjun,Liu, Lisha,Chen, Xinli,Ruan, Chunhui,Sun, Tao,Jiang, Chen

, p. 3409 - 3421 (2017)

Most small molecular chemotherapeutics have poor water solubility and unexpected pharmacokinetics and toxicity to normal tissues. A series of nano drug delivery systems have been developed to solve the problems, among which a micelle based on linear-dendritic polymer-drug conjugates (LDPDCs) is a promising strategy to deliver hydrophobic chemotherapeutics due to its small size, fine stability in blood circulation, and high drug loading capacity. In this work we synthesized a novel amphiphilic linear-dendritic PEG-PTX8 conjugate which can also encapsulate extra free PTX and self-assemble into uniform ultrasmall micelles with a hydrated diameter of 25.50 ± 0.27 nm. To realize efficient drug delivery to tumor sites, a cyclic tumor homing and penetrating peptide iNGR was linked to the PEG-PTX8 conjugate. The biological evaluation was performed on a human triple negative breast cancer model. PTX accumulation in tumor at 24 h of the TNBC-bearing mice treated with iNGR-PEG-PTX8/PTX micelles was significantly enhanced (P 8/PTX micelles. Furthermore, iNGR-PEG-PTX8/PTX micelles showed an obvious strong antitumor effect, and the median survival time of TNBC bearing mice treated with iNGR-modified micelles was significantly extended compared to Taxol. Therefore, this smart micelle system may be a favorable platform for effective TNBC therapy.

Selective monobenzylation of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) to yield an AB linear monomer and analogous linear oligomers

Giesen, Joseph A.,Grayson, Scott M.

supporting information, (2020/05/28)

The synthesis of a mono-benzylated AB monomer based on bis-MPA is explored and accomplished via a three-step synthesis without column chromatography. This optimized synthesis utilizes a generic acid-catalyzed esterification of bis-MPA to the ethyl ester.

Polymeric conjugates of active principles, their process of preparation and their polymeric intermediates

-

Page/Page column 12, (2016/06/01)

The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates.

The first peripherally masked thiol dendrimers: A facile and highly efficient functionalization strategy of polyester dendrimers via one-pot xanthate deprotection/thiol-acrylate Michael addition reactions

Auty, Sam E. R.,Andrén, Oliver,Malkoch, Michael,Rannard, Steven P.

supporting information, p. 6574 - 6577 (2014/06/10)

Introducing multiple reactive functional groups at the periphery of dendrimer materials presents considerable challenges if the functionality is able to self-react. An efficient and facile approach to introducing masked thiols at the surface of polyester dendrimers is presented. One-pot, deprotection/thiol-acrylate Michael addition from the xanthate-functional dendritic substrates (generation zero to two) has been achieved for the first time, with high efficiency demonstrated using three acrylates of varying chemistry and avoiding disulfide formation. This journal is the Partner Organisations 2014.

METHOD FOR PREPARING TEMSIROLIMUS

-

Paragraph 0028, (2013/11/19)

A method for preparing temsirolimus, the method including: using a substituted aromatic aldehyde to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out reaction between the intermediate II and 2,4,6-trichlorobenzoyl chloride; carrying out condensation reaction between a resulting product and rapamycin to produce intermediate III; and finally using sulfuric acid to remove a protecting group from the intermediate III to yield temsirolimus.

PROCESS FOR PREPARING TORISEL

-

Paragraph 0022, (2013/12/02)

A process for preparing Torisel, which is a derivative of Rapamycin, is provided. The process comprises the following steps: acetalating 2,2-dihydroxymethylpropionic acid with substituted or unsubstituted aromatic aldehyde in the presence of p-toluenesulfonic acid as catalyst to form the intermediate II; reacting the obtained intermediate with 2,4,6-trichlorobenzoyl chloride; then esterifying the obtained chloride with Rapamycin and finally deprotecting the diol to provide the product Torisel with yield over 35.6%. The aromatic aldehyde is one selected from benzaldehyde, p-methoxybenzaldehyde, p-chlorobenzaldehyde and p-trifluoromethyl benzaldehyde.

8-Azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

-

Page/Page column 39, (2008/06/13)

The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

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