41095-07-2

Basic information

• Product Name: 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE
• CAS NO: 41095-07-2
• Molecular Formula: C₁₂H₁₄ClN₃O₂
• Molecular Weight: 267.71146
• Mol File: 41095-07-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER(41095-07-2)
• EPA Substance Registry System: 4-CHLORO-1-ETHYL-6-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER(41095-07-2)

Safety Data

• Hazardous Substances Data: 41095-07-2(Hazardous Substances Data)

Upstream product

• 3528-58-3 5-Amino-1-ethylpyrazole 
• 3044-06-2 diethyl 2-(1-ethoxyethylidene)malonate 
• 570-08-1 diethyl acetylmalonate 
• 28783-52-0 2-(1-chloro-ethylidene)-malonic acid diethyl ester 
• 41095-06-1 1-ethyl-6-methyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 

Downstream Products

• 41094-88-6 tracazolate 
• 89866-21-7 4-Amino-1-benzyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 89866-20-6 1-Benzyl-4-ethoxy-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 89866-55-7 4-Amino-6-methyl-1-(2-cyclopropylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Relevant articles and documents

PHOSPHODIESTARASE INHIBITORS

The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, f

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x): and wherein: Q1 is NH or NMe, in which case Q2 is -C(O)-, -S(O)2-, -C(O)NH- or -C(O)NMe-; or Q1 is a bond o

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: wherein R2 is H, C1-3alkyl, n butyl, C1-2fluoroalkyl, cyclopropyl, cyclobutyl, (cyclopropyl)methyl , CN, or CH2OH; R3 is inter alia optionally substituted C4-7cycloalkyl or an optionally substituted heterocyclic group (aa), (bb) or (cc); Ra is H, methyl or ethyl; Rb is H or methyl; R4 is H, methyl, ethyl, n propyl, C(O) Me, or C(O) C1fluoroalkyl; and R5 is: C(O) (CH2)n Ar, C(O) Het, C(O) C1 6alkyl, C(O) C1fluoroalkyl, C(O) (CH2)2 C(O) NR15bNR15b, C(O) CH2 C(O) NR15bNR15b, C(O) NR15b (CH2)m1 Ar, C(O) NR15b Het, C(O) NR15b C1-6 alkyl, C(O) NR5aR5b, S(O)2 (CH2)m2-Ar, S(O)2 Het, S(O)2-C1-6alkyl, or CH2 Ar; or R4 and R5 taken together are-(CH2)p1-, (CH2)2 X5 (CH2)2 , C(O) (CH2)p2 ,-C(O)-N(R15) (CH2)p3 ; or NR4R5 is of sub-formula (y), (y1), (y2) or (y3). The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, allergic rhinitis, psoriasis or atopic dermatitis.