35296-53-8

Upstream product

• 87-51-4 indole-3-acetic acid 
• 108-24-7 acetic anhydride 
• 2258-42-6 formyl acetic anhydride 
• 91569-49-2 (2-acetyl-3-indolyl)acetic acid 

Downstream Products

• 118361-72-1 methyl 1-methyl-2-phenyl-9H-carbazole-3-carboxylate 
• 118361-73-2 methyl 1-methyl-3-phenyl-9H-carbazole-2-carboxylate 
• 6510-65-2 1-methyl-9H-carbazole 
• 132932-77-5 3-Benzenesulfonyl-1-methyl-9H-carbazole 
• 118361-65-2 1-methyl-3-phenyl-9H-carbazole 
• 94193-96-1 2,3-dibenzoyl-1-methyl-9H-carbazole 
• 118042-95-8 1-Methyl-2-phenyl-9H-carbazol-3-carbonsaeure-ethylester 
• 118042-96-9 1-Methyl-3-phenyl-9H-carbazol-2-carbonsaeure-ethylester 
• 836608-15-2 2-acetylindol-3-ylacetic acid 4-methoxylphenylamide 
• 836608-13-0 2-(2-acetyl-1H-indol-3-yl)-N-phenyl-acetamide 
• 1097884-95-1 2-(benzoylamino)-1-methyl-2,9-dihydro-3H-β-carbolin-3-one 
• 1097884-80-4 2-anilino-1-methyl-2,9-dihydro-3H-β-carbolin-3-one 
• 1192284-10-8 4-benzyl-5-methyl-4,6-dihydro[1,3]diazepino[5,6-b]indol-3(2H)-one 
• 16244-23-8 2-acetyl-3-methylindole 

Relevant academic research and scientific papers

Electrophilic substitution of dimethyl 1 -methylcarbazole-2,3-dicarboxylate: Synthesis of new b-fused carbazoles as potential antitumor agents

1-Methylcarbazole-2,3-dicarboxylic acid dimethyl ester, a key intermediate in the synthesis of b-fused carbazoles, was successfully transformed into its 6-bromo and 6-nitro derivative via electrophilic substitution in acetic acid solution, using N-bromosuccinimide or urea nitrate, respectively, as reagents. With N-chlorosuccinimide, a 6,8-dichloro congener was also obtained in substantial amounts. The 6-substituted carbazolediesters were used as building blocks for the preparation of several new pyridazine- or pyrrole-fused carbazoles with basic side chains, featuring the core structure of previously developed antitumor compounds.

The Mechanism of Formation of 3H,9H-Pyranoindol-3-ones from 3-Indolalkanoic Acids

The mechanism of the formation of 1-methyl-3H,9H-pyranoindol-3-one (4) from the corresponding 3-indolacetic acid 1 is discussed.The suggested mechanism is substantiated by the isolation of a stable intermediate 2 and its transformations in the presence of acetic anhydride and/or Lewis acids. Key Words: 3H,9H-Pyranoindole derivative / Indole derivatives

Synthesis of the Carbazole Alkaloids Carbazomycin A and B and Hyellazole

The first synthesis of carbazomycins A and B (1) is described; the route involves Diels-Alder reaction of 1-methylpyranoindol-3-one with ethyl 3-trimethylsilylpropynoate followed by functional group interconversions; the marine alkaloid hyellazole