16244-23-8Relevant articles and documents
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Somei,M.,Natsume,M.
, p. 2451 - 2454 (1973)
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Zhungietu et al.
, (1970)
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Sulfated Zirconia: An Efficient and Reusable Heterogeneous Catalyst in the Friedel–Crafts Acylation Reaction of 3-Methylindole
Vargas, Darío A.,Méndez, Leticia J.,Cánepa, Alicia S.,Bravo, Rodolfo D.
, p. 1496 - 1502 (2017/08/29)
Abstract: An efficient process for the Friedel–Crafts acylation of 3-methylindole with acid anhydrides in the presence of sulfated zirconia was developed. This catalyst shows excellent catalytic activity with good conversion and selectivity towards formation of the products of 2-acylation (3-methyl-1H-indol-2-yl)ketones. Other advantages related to this process are the simple work-up procedure and smaller production of chemical waste. The catalyst was easily recycled and reused with a minimal loss in activity through three reaction cycles. The catalyst was characterized by FT-IR spectroscopy, X-Ray diffraction and superficial acidity. Graphical Abstract: [Figure not available: see fulltext.].
Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines
Giles, Robert G.,Heaney, Harry,Plater, M. John
, p. 7367 - 7385 (2015/08/24)
Abstract Reactions of N-methyl- and N-ethyl-nitrilium salts with indole and pyrrole and their derivatives yield imines or imine salts in good yields. The related imines are obtained from the salts after careful basification and hydrolysis of the imine salts or the imines by heating with aqueous base give the related ketones in good yields. Alternatively, the imine salts can be reduced using sodium borohydride in methanol to give the related secondary amines.
Cyclocondensation reactions between 2-acyl-3-indoleacetic acid derivatives and phenylglycinol: Enantioselective synthesis of 1-substituted tetrahydro-β-carboline alkaloids
Amat, Mercedes,Subrizi, Fabiana,Elias, Viviane,Llor, Nuria,Molins, Elies,Bosch, Joan
scheme or table, p. 1835 - 1842 (2012/05/05)
Cyclocondensation reactions between a variety of 2-acyl-3-indoleacetic acid derivatives and (R)-phenylglycinol were studied. Successful results were obtained from N-alkyl keto acid derivatives. The resulting tetracyclic lactams provide straightforward access to enantiopure 1-substituted tetrahydro-β- carboline alkaloids.
