35302-70-6

Usage

Uses

Used in Pharmaceutical Applications:
Pinosylvin mono methyl ether is used as a therapeutic compound for its potential health benefits, including its antimicrobial and antifungal properties. It is being studied for its potential to treat various diseases and as a natural alternative to synthetic preservatives in pharmaceutical products.
Used in Food Industry:
Pinosylvin mono methyl ether is used as a natural preservative in food products to extend their shelf life and maintain their quality. Its antimicrobial properties help prevent spoilage and contamination, making it a safer and healthier alternative to synthetic preservatives.
Used in Cosmetic Industry:
Pinosylvin mono methyl ether is used as a natural preservative in cosmetic products to prevent microbial growth and ensure product safety. Its antioxidant and anti-inflammatory properties also contribute to the overall efficacy and benefits of cosmetic formulations.
Used in Antimicrobial Applications:
Pinosylvin mono methyl ether is used as an antimicrobial agent to combat various types of bacteria and fungi. Its broad-spectrum activity makes it a promising candidate for use in medical and industrial settings to prevent infections and contamination.
Used in Antifungal Applications:
Pinosylvin mono methyl ether is used as an antifungal agent to treat and prevent fungal infections. Its ability to inhibit fungal growth makes it a valuable component in antifungal medications and treatments.
Used in Antioxidant Applications:
Pinosylvin mono methyl ether is used as an antioxidant to protect cells from oxidative stress and damage caused by free radicals. Its antioxidant properties contribute to the overall health and well-being of individuals, making it a valuable component in dietary supplements and health products.
Used in Anti-inflammatory Applications:
Pinosylvin mono methyl ether is used as an anti-inflammatory agent to reduce inflammation and alleviate pain associated with various conditions. Its ability to modulate inflammatory pathways makes it a promising candidate for the treatment of inflammatory diseases.

InChI:InChI=1/C15H14O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-11,16H,1H3/b8-7+

Upstream product

• 1449-46-3 benzyltriphenylphosphonium bromide 
• 100-39-0 benzyl bromide 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 21956-56-9 (E)-3,5-dimethoxystilbene 

Downstream Products

• 133462-46-1 2-((E)-3,7-Dimethyl-octa-2,6-dienyl)-1,5-dimethoxy-3-phenethyl-benzene 
• 133462-42-7 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl 
• 70610-15-0 2,2-dimethyl-5-hydroxy-7-(2-phenylethyl)chroman 
• 98156-06-0 dihydroamorphastilbol dimethyl ether 
• 133462-73-4 1,5-Dimethoxy-2-(3-methyl-but-2-enyl)-3-phenethyl-benzene 
• 133462-43-8 3-hydroxy-5-methoxy-2-(3-methyl-2-butenyl)bibenzyl 
• 133462-72-3 3-hydroxy-5-methoxy-2-(3-methyl-2-butenyl) bibenzyl 
• 133462-75-6 3,5-dihydroxy-2-(2,3-epoxy-3-methylbutyl)bibenzyl 
• 133462-79-0 5-Methoxy-2,2-dimethyl-7-phenethyl-2H-chromene 
• 133462-77-8 methyl ether 2,2-dimethyl-7-hydroxy-5-(2-phenylethyl)chromene 
• 78916-45-7 2,2-dimethyl-7-hydroxy-5-(2-phenylethyl) chroman 
• 133462-94-9 2,6-dibromo-3,5-dimethoxy-bibenzyl 
• 78916-50-4 1,3-dimethoxy-5-(2-phenylethyl)benzene 
• 70610-10-5 3-methoxy-2-(3-methylbut-2-enyl)-5-(1-phenylethyl)phenol 

Relevant academic research and scientific papers

Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor

A series of 31 resveratrol derivatives was designed, synthesized and evaluated for activation and inhibition of the TRPA1 channel. Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC). Compound 4z (HUHS029) exhibited higher inhibitory activity than resveratrol with an IC50 value of 16.1?μM. The activity of 4z on TRPA1 was confirmed in TRPA1-expressing HEK293 cells, as well as in rat dorsal root ganglia neurons by a whole cell patch clamp recording. Furthermore, pretreatment with 4z exhibited an analgesic effect on AITC-evoked TRPA1-related pain behavior in vivo.

New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis

An antimicrobial phenolic stilbene, (E)-3-hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methici

An efficient palladium-catalyzed Negishi cross-coupling reaction with arylvinyl iodides: facile regioselective synthesis of E-stilbenes and their analogues

A general synthetic route for the Pd-catalyzed cross-coupling of an arylzinc reagent with arylvinyl iodides (Negishi cross-coupling) has been developed. The system permits efficient and selective preparation of E-stilbenes and their analogues. It also functions effectively at low levels of catalyst loading without the need for an additional ligand and tolerates a wide range of functional groups including heteroaromatic substrates. A systematic study of various parameters was performed and correlated with catalyst-substrate activity.

Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells

The inhibitory effects of pinosylvin analogues on the production of COX-2 mediated PGE2 were evaluated in a cell culture system. A new series of potential inhibitors, including 3-hydroxy-5-benzyloxy-trans-stilbene and 3,5-dimethoxy-trans-stilbene, have been identified. A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.

Pest control chemicals against pine wood nematodes

Disclosed are (1) pest control chemicals against the pine wood nematodes containing an extract from a pine tree with an organic solvent, (2) a repellent against the pine wood nematodes containing α-humulene or a mixture of α-humulene and β-bisabolene, (3) a repellent against the pine wood nematodes containing a mixture of α-pinene and calarene, (4) a nematicide against the pine wood nematodes containing methyl ferulate, (+)-pinoresinol or a mixture thereof, and (5) highly effective pest control chemicals against pine wood nematodes containing hydroxystilbenes or salts thereof which are prepared by synthesizing methoxystilbenes from benzyl phosphonates and methoxybenzaldehydes by a Wittig-Horner reaction, performing demethylation to obtain the hydroxystilbenes, and preparing the salts thereof by conventional methods if necessary.

Synthesis and nematocidal activity of hydroxystilbenes

Various (E)-hydroxystilbenes were synthesized from (E)/(Z) mixtures of methoxystilbenes through a new (Z)-(E) isomerization method followed by demethylation. The nematocidal activity appears when methoxystilbenes are demethylated to hydroxystilbenes. For this activity, a hydroxy group at the C-2 or C-3 position is necessary. Thus, 2-hydroxy-, 3-hydroxy-, 2,6-dihydroxy-, 3,4-dihydroxy-, 3,5-dihydroxy-, 2,2'-dihydroxy-, 3,3'-dihydroxy-, 3,4'dihydroxy-, 2-hydroxy-4-methoxy-, 5-hydroxy-2-methoxy-, 2-hydroxy-6-methoxy-, 6-allyloxy-2-hydroxy-, 3-hydroxy-5-methoxy-, and 5-allyloxy-3-hydroxystilbenes showed rather potent nematocidal activity. The activity of 5-allyloxy-3-hydroxystilbene was the strongest [minimal lethal concentration (MLC) = 30 μM]. The activities of the (E) and (Z) isomers were comparable. The activities were also retained, though they were weaker, in the dihydro derivatives, hydroxybibenzyls.