35307-35-8

Basic information

• Product Name: Benzofuran, 3-(4-methylphenyl)-2-phenyl-
• CAS NO: 35307-35-8
• Molecular Formula: C21H16O
• Molecular Weight: 284.357
• Mol File: 35307-35-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzofuran, 3-(4-methylphenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 3-(4-methylphenyl)-2-phenyl-(35307-35-8)
• EPA Substance Registry System: Benzofuran, 3-(4-methylphenyl)-2-phenyl-(35307-35-8)

Safety Data

• Hazardous Substances Data: 35307-35-8(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 533-58-4 2-Iodophenol 
• 41398-67-8 2-phenylethynylanisole 
• 5720-05-8 4-methylphenylboronic acid 
• 246230-86-4 3-iodo-2-phenylbenzo[b]furan 
• 955-10-2 3-phenylcumarin 
• 106-38-7 para-bromotoluene 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 116544-58-2 [2-(4-Methyl-benzoyl)-phenoxy]-phenyl-acetic acid ethyl ester 
• 874-60-2 4-methyl-benzoyl chloride 
• 36414-60-5 2-bromo-1-phenyl-2-(p-tolyl)ethan-1-one 
• 19434-30-1 2-hydroxy-4'-methylbenzophenone 
• 93-99-2 benzoic acid phenyl ester 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

Indium(III)-Catalyzed Synthesis of Benzo[ b]furans by Intramolecular Hydroalkoxylation of ortho-Alkynylphenols: Scope and Mechanistic Insights

Indium(III) halides catalyze the hydroalkoxylation reaction of ortho-alkynylphenols to afford benzo[b]furans in good yields. The reaction proceeds with 5-endo-dig regioselectivity with a variety of phenols functionalized at the arene and alkyne moieties in high yields using InI3 (5 mol %) in DCE. Experimental and computational studies support a mechanism based on the indium(III) π-Lewis acid activation of the alkyne followed by nucleophilic addition of the phenol and final protodemetalation to afford the corresponding benzo[b]furan. DFT calculations suggest that dimer In2I6 is the catalytic species through a novel double coordination with the alkyne and the hydroxyl group.

A one-pot domino C-H, C-C activation in coumarins: A fast track to 2,3-diaryl benzo[b]furans

An approach to synthesize 2,3-diaryl benzo[b]furans using coumarins and aryl bromides is developed. This state-of-the-art strategy capitalizes on a palladium-catalyzed one-pot decarbonylative diarylation of coumarins, paving the way to achieve biologicall

Synthesis of Conformationally Restricted 2,3-Diarylbenzo[b]furan by the Pd-Catalyzed Annulation of o-Alkynylphenols: Exploring a Combinatorial Approach

The palladium/bpy-catalyzed annulation of o-alkynylphenol with various aryl halides to generate diversified 2,3-diarylbenzo[b]furan is herein described. This method provides an efficient synthetic pathway for the combinatorial synthesis of conformationally restricted 2,3-diarylbenzo[b]furan for drug discovery.