3532-75-0Relevant academic research and scientific papers
Facile synthesis of non-nucleoside compounds starting from a-chlorocarbenium ions and isocyanates as potential hiv-1 reverse transcriptase inhibitors
Hamed, Atef A.,Zeid, Ibrahim F.,Manaa, Alaa A.
experimental part, p. 555 - 564 (2010/03/03)
Chloro(phenyl)carbenium hexachloroantimonate salts react with isocyanates to afford either isoindolium (1) or benzoxazinium salts (2). Addition of one equivalent of alcohol to 2 led, after hydrolysis with aq. NaOH, to the formation of benzoxazin-2-ones 3. Treatment with a large excess of alcohol transformed the salts 1 and 2 to the corresponding isoindol-1-ones 11 and the isocyanates 5, respectively. Reaction of 5 with primary amines furnished the urea derivatives 6 in good yield. The biological activity of 6a - o against HIV-1 was determined.
Some Isoindolo-fused Heterocyclic Systems by Cyclodehydration of N-Arylalkyl-3-hydroxyphthalimidines
Hitchings, Gregory J.,Helliwell, Madeleine,Vernon, John M.
, p. 83 - 87 (2007/10/02)
α-Hydroxy-lactams formed by reduction or Grignard addition to appropriately N-substituted phthalimides (1a-d) undergo acid-catalysed cyclodehydration to derivatives of the isoindolo-fused heterocyclic systems (6)-(10).Ring closures to the naphthalene 2- or 8-position are observed to occur with N-1-naphthylalkyl substituents, the latter proved by an X-ray crystal structure determination of 13b-phenyl-7H-benzisoindoloisoquinolin-9(13H)-one (9b).
