353227-95-9

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 918306-77-1 C₁₉H₁₈O₆ 
• 156-38-7 4-hydroxyphenylacetate 
• 116518-98-0 E-3-(3,5-dimethoxy-phenyl)-2-(4-hydroxy-phenyl)-acrylic Acid 

Downstream Products

• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 
• 1032508-00-1 trans-3',5'-dimethoxy-4-mercaptostilbene 
• 1032508-02-3 (E)-S-4-(3,5-dimethoxystyryl)phenyl dimethylcarbamothioate 
• 1032508-01-2 (E)-O-4-(3,5-dimethoxystyryl)phenyl dimethylcarbamothioate 
• 606932-86-9 (Z)-3-(3,5-dimethoxyphenyl)-2-[4-(4-formylphenoxy)phenyl]acrylic acid methyl ester 
• 606932-85-8 (Z)-3-(3,5-dimethoxyphenyl)-2-(4-hydroxyphenyl)acrylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents

A number of 2,4-thiazolidinedione derivatives of -phenyl substituted cinnamic acid were synthesized and studied for their PPAR agonist activity. The E-isomer of cinnamic acid, 11, showed moderate PPAR transactivation. The corresponding Z-isomer, 23, and d

Laccase-catalyzed dimerization of hydroxystilbenes

A series of hydroxystilbenes, analogues of the bioactive phytoalexin resveratrol, were synthesized and submitted to the catalytic action of a laccase from Trametes pubescens in a biphasic system made of ethyl acetate and acetate buffer. Oxidation took place at the 4′-hydroxy (4-hydroxy) position of the hydroxystilbenic moieties, followed by radical-radical coupling dimerization reactions. Most of the products were isolated in good yields and fully characterized. Depending on the substrates, three different dimeric products could be identified, the main products usually being 4-O-α-β-5 (dihydrofuran-like) dimers.

Novel heterocyclic analogs of diphenylethylene compounds

Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.