606932-86-9

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 606932-85-8 (Z)-3-(3,5-dimethoxyphenyl)-2-(4-hydroxyphenyl)acrylic acid methyl ester 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 353227-95-9 α-[(3,5-dimethoxyphenyl)methylene]-4-hydroxy-(αZ)-benzeneacetic acid 
• 116518-98-0 E-3-(3,5-dimethoxy-phenyl)-2-(4-hydroxy-phenyl)-acrylic Acid 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents

A number of 2,4-thiazolidinedione derivatives of -phenyl substituted cinnamic acid were synthesized and studied for their PPAR agonist activity. The E-isomer of cinnamic acid, 11, showed moderate PPAR transactivation. The corresponding Z-isomer, 23, and d

Novel heterocyclic analogs of diphenylethylene compounds

Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.