353259-48-0Relevant academic research and scientific papers
An efficient route to 4-aryloxycoumarins via one-pot reactions of 4-hydroxycoumarins with hypervalent iodine reagents
Gao, Wei,Xu, Linchu,Gong, Chun,Ding, Qiuping,Peng, Yiyuan
supporting information, p. 4020 - 4023 (2017/09/26)
Highly efficient reactions of 4-hydroxycoumarin with hypervalent iodine reagents under mild conditions are described, which give rise to 4-aryloxycoumarins in good to excellent yields.
Pd/Indanone-Based Ligands: An Efficient Catalyst System for Ullmann-Type, Suzuki-Miyaura, and Mizoroki-Heck Cross-Coupling Reactions with Aryl Tosylates and Aryl Halides
Waheed, Mohammed,Ahmed, Naseem
, p. 4372 - 4382 (2017/09/12)
2-Hydroxyindan-1-ones have been efficiently synthesized and successfully applied as ligands in Pd-catalyzed Ullmann type, Suzuki-Miyaura, and Mizoroki-Heck cross-coupling reactions with aryl tosylates and aryl halides. The ligands are air- and moisture-stable and have shown high catalytic activity with Pd(OAc) 2 in these cross-coupling reactions. The system tolerates a variety of functional groups in the product and can be re-used at least three times with maximum efficiency..
Cyclization of 4-Phenoxy-2-coumarins and 2-Pyrones via a Double C-H Activation
Mackey, Katrina,Pardo, Leticia M.,Prendergast, Aisling M.,Nolan, Marie-T.,Bateman, Lorraine M.,McGlacken, Gerard P.
, p. 2540 - 2543 (2016/06/15)
Aryl-heteroaryl coupling via double C-H activation is a powerful transformation that avoids the installation of activating groups. A double C-H activation of privileged biological scaffolds, 2-coumarins and 2-pyrones, is reported. Despite the rich chemistry of these molecular frameworks, the yields are very good. Excellent regioselectivity was achieved on the pyrones. This methodology was applied to the synthesis of flemichapparin C in three steps. Isotope effect experiments were carried out, and a mechanism is proposed.
