353460-45-4

Upstream product

• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 108-86-1 bromobenzene 
• 73172-56-2 ethyl 4-benzoylbutanoate 
• 17851-44-4 ethyl 6-phenyl 5,5-(ethylenedioxy)hexanoate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 75424-63-4 5-oxo-5-phenylpentanal 
• 1011-62-7 5-hydroxy-1-phenylpentan-1-one 
• 165613-10-5 5,5-(ethylenedioxy)-5-phenylpentanal 
• 17851-47-7 4-(2-phenyl-1,3-dioxolan-2-yl)-1-butanol 

Downstream Products

• 1396203-45-4 isopropyl 2-((2R,6S)-6-phenyltetrahydro-2H-pyran-2-yl)acetate 

Relevant academic research and scientific papers

Enantioselective synthesis of 2,6-cis-disubstituted tetrahydropyrans via a tandem catalytic asymmetric hydrogenation/oxa-Michael cyclization: An efficient approach to (-)-centrolobine

A highly efficient one-pot process via a tandem reaction of catalytic asymmetric hydrogenation and oxa-Michael cyclization for the synthesis of 2,6-cis-disubstituted tetrahydropyrans has been developed (ee up to 99.9%, cis/trans-selectivity up to 99:1). T

The First Tandem [2 + 2] Cycloaddition-Michael Reaction Using Ynolates: Facile Construction of Substituted Carbocycles

(matrix presented) A tandem [2 + 2] cycloaddition-Michael reaction using ynolate anions followed by decarboxylation produced polysubstituted five-, six-, and seven-membered cycloalkenes.