353460-45-4Relevant articles and documents
Enantioselective synthesis of 2,6-cis-disubstituted tetrahydropyrans via a tandem catalytic asymmetric hydrogenation/oxa-Michael cyclization: An efficient approach to (-)-centrolobine
Xie, Jian-Hua,Guo, Lu-Chuan,Yang, Xiao-Hui,Wang, Li-Xin,Zhou, Qi-Lin
, p. 4758 - 4761,4 (2012/12/13)
A highly efficient one-pot process via a tandem reaction of catalytic asymmetric hydrogenation and oxa-Michael cyclization for the synthesis of 2,6-cis-disubstituted tetrahydropyrans has been developed (ee up to 99.9%, cis/trans-selectivity up to 99:1). T