353498-24-5

Upstream product

• 4291-14-9 phenyl-1,3,4-thiadiazole 
• 4291-16-1 thioformic acid N'-benzoyl-hydrazide 
• 1148122-61-5 N′-formyl-2-nitrobenzohydrazide 
• 606-26-8 o-nitrobenzohydrazide 
• 552-16-9 ortho-nitrobenzoic acid 
• 606-27-9 methyl 2-nitrobenzoate 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 874507-60-5 2-(1,3,4-thiadiazol-2-yl)aniline 
• 53567-02-5 2-(2-hydroxyphenyl)-1,3,4-thiadiazole 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING CANCER

Substituted cinnamamide compounds and analogs, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate cancer are provided.

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.