53567-02-5

Basic information

• Product Name: 2-(2-hydroxyphenyl)-1,3,4-thiadiazole
• CAS NO: 53567-02-5
• Molecular Weight: 178.214
• Mol File: 53567-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-hydroxyphenyl)-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxyphenyl)-1,3,4-thiadiazole(53567-02-5)
• EPA Substance Registry System: 2-(2-hydroxyphenyl)-1,3,4-thiadiazole(53567-02-5)

Safety Data

• Hazardous Substances Data: 53567-02-5(Hazardous Substances Data)

Upstream product

• 4291-14-9 phenyl-1,3,4-thiadiazole 
• 4291-16-1 thioformic acid N'-benzoyl-hydrazide 
• 1010-85-1 N'-formyl-2-hydroxybenzohydrazide 
• 119-36-8 methyl salicylate 
• 70203-02-0 N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 613-94-5 benzoic acid hydrazide 
• 353498-24-5 2-(2-nitrophenyl)-1,3,4-thiadiazole 
• 874507-60-5 2-(1,3,4-thiadiazol-2-yl)aniline 

Relevant articles and documents

Synthesis and Biological Evaluation of Some Heterocyclic Compounds from Salicylic Acid Hydrazide

Different heterocyclic compounds were prepared starting from 2-hydroxy benzohydrazide; for example, cyclization of hydrazide hydrazone 3 derived from 2-hydroxybenzohydrazide 2 with acetic anhydride or concentrated sulfuric acid gave 1,3,4-oxadiazole derivatives 4–5. On the other hand, direct cyclization of 2-hydroxy benzohydrazide 2 with one carbon cyclizing agent gave a new derivative of 1,3,4-oxadiazole 7, 8, 9, 10, 11. Heating of hydrazide hydrazone 3 with thioglycolic acid in pyridine gave thiazolidinone 12. When 2-hydroxy benzohydrazide 2 reacted with aliphatic carboxylic acids such as formic acid or acetic acid, it gave the corresponding N-formyl or N-acetyl derivatives 6. Subsequent cyclization of 6 using phosphorous pentasulphide in pyridine gave 1,3,4-thiadiazoles 13. Cyclization of 2-hydroxy benzohydrazide with ethyl acetoacetate gives pyrazolone derivative 14. Finally, when an ethanolic solution of acid hydrazide 2 was treated with ammonium thiocyanate in 35% HCl, it gave the thiosemicarbazide 15. Subsequent treatment of 15 with concentrated sulfuric acid or 10% sodium hydroxide gave 5-amino-1,3,4-thiadiazole 16 and 1,2,4-triazole 17, respectively. The structures of all newly isolated compounds were confirmed using1H NMR, IR spectra, and elemental analyses. The antimicrobial activities for all isolated compounds were examined against different microorganisms.