353517-00-7Relevant articles and documents
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
Harrell, William A.,Vieira, Rebecca C.,Ensel, Susan M.,Montgomery, Vicki,Guernieri, Rebecca,Eccard, Vanessa S.,Campbell, Yvette,Roxas-Duncan, Virginia,Cardellina, John H.,Webb, Robert P.,Smith, Leonard A.
, p. 675 - 678 (2017)
Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to investigate this flexibility and
