Bioorganic and Medicinal Chemistry Letters p. 675 - 678 (2017)
Update date:2022-09-26
Topics: Data Analysis Structure-Activity Relationship (SAR) Methodology
Harrell, William A.
Vieira, Rebecca C.
Ensel, Susan M.
Montgomery, Vicki
Guernieri, Rebecca
Eccard, Vanessa S.
Campbell, Yvette
Roxas-Duncan, Virginia
Cardellina, John H.
Webb, Robert P.
Smith, Leonard A.
Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to investigate this flexibility and
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