35356-56-0

Basic information

• Product Name: N-phenyl-5-pyridin-3-yl-1,3,4-thiadiazol-2-amine
• Synonyms: N-phenyl-5-pyridin-3-yl-1,3,4-thiadiazol-2-amine
• CAS NO: 35356-56-0
• Molecular Formula: C₁₃H₁₀N₄S
• Molecular Weight: 254.3103
• Mol File: 35356-56-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-phenyl-5-pyridin-3-yl-1,3,4-thiadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-5-pyridin-3-yl-1,3,4-thiadiazol-2-amine(35356-56-0)
• EPA Substance Registry System: N-phenyl-5-pyridin-3-yl-1,3,4-thiadiazol-2-amine(35356-56-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 35356-56-0(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 553-53-7 Nicotinic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 
• 500-22-1 3-pyridinecarboxaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 54809-91-5 2-nicotinoyl-N-phenylhydrazinecarboxamide 
• 67526-46-9 (E)-N-phenyl-2-(pyridin-3-ylmethylene)hydrazine-1-carbothioamide 
• 54584-49-5 N-phenyl-2-(pyridin-3-ylcarbonyl)hydrazinecarbothioamide 

Relevant articles and documents

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Synthesis of substituted 1,3,4-thiadiazoles using Lawesson's reagent

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Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles.

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