35356-56-0

Upstream product

• 54809-91-5 2-nicotinoyl-N-phenylhydrazinecarboxamide 
• 500-22-1 3-pyridinecarboxaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 59-67-6 nicotinic acid 
• 553-53-7 Nicotinic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 
• 67526-46-9 (E)-N-phenyl-2-(pyridin-3-ylmethylene)hydrazine-1-carbothioamide 
• 54584-49-5 N-phenyl-2-(pyridin-3-ylcarbonyl)hydrazinecarbothioamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

PESTICIDAL COMPOSITIONS

Molecules according to Formula One: and their uses are disclosed herein.