35368-68-4

Usage

Uses

Used in Agricultural Industry:
2-(2-Chlorophenoxy)acetamide is used as a herbicide for controlling the growth of annual and perennial grasses in crops such as sugarcane, cotton, and soybeans. It is applied to achieve stunted growth and eventual death of the targeted weeds by inhibiting the synthesis of gibberellin, a key plant hormone.
However, it is important to note that the use of 2-(2-Chlorophenoxy)acetamide, or dalapon, is accompanied by potential health and environmental concerns. It has been classified as a possible human carcinogen and is toxic to aquatic organisms, necessitating strict regulation of its application in many countries to mitigate these risks.

InChI:InChI=1/C8H8ClNO2/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4H,5H2,(H2,10,11)

Upstream product

• 95-57-8 2-monochlorophenol 
• 614-61-9 (2-chlorophenoxy)acetic acid 
• 20143-41-3 (2-chloro-phenoxy)-acetyl chloride 
• 79-07-2 Chloroacetamide 

Downstream Products

• 614-61-9 (2-chlorophenoxy)acetic acid 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 344269-49-4 methyl 2-chloro-4-chloromethylsulfonylphenoxyacetate 
• 78843-06-8 2-chloro-4-chloromethylsulfonylphenoxyacetic acid 

Relevant academic research and scientific papers

A phenoxy acetyl amine compound preparation method and phenoxy acetamide compounds

The invention belongs to the organic intermediates and the technical field of pharmaceutical intermediates, in particular to a phenoxy acetyl amine compound preparation method and phenoxy acetyl amine compound. The present invention provides a preparation method of the pervasive should be good, and green environmental protection, has better popularization and application value. The results show that the embodiment, the invention provides the above-mentioned method can prepare a plurality of phenoxy acetyl amine compound, and the yield can be 76%.

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.