3537-62-0Relevant articles and documents
Iron-Catalyzed, Fluoroamide-Directed C-H Fluorination
Groendyke, Brian J.,Abusalim, Deyaa I.,Cook, Silas P.
supporting information, p. 12771 - 12774 (2016/10/13)
This communication describes a mild, amide-directed fluorination of benzylic, allylic, and unactivated C-H bonds mediated by iron. Upon exposure to a catalytic amount of iron(II) triflate (Fe(OTf)2), N-fluoro-2-methylbenzamides undergo chemoselective fluorine transfer to provide the corresponding fluorides in high yield. The reaction demonstrates broad substrate scope and functional group tolerance without the use of any noble metal additives. Mechanistic and computational experiments suggest that the reaction proceeds through short-lived radical intermediates with F-transfer mediated directly by iron.
Convenient syntheses of 1,3-dihydro-1-oxo-4-isobenzofurancarboxylic acid, 1,3-dihydro-3-oxo-4-isobenzofurancarboxylic acid, and the homologous acetic acids
Skeean,Goel
, p. 628 - 630 (2007/10/02)
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