35376-72-8Relevant academic research and scientific papers
Living Polymerization of 2-Ethylthio-2-oxazoline and Postpolymerization Diversification
Wu, You-Chi Mason,Swager, Timothy M.
, p. 12498 - 12501 (2019)
The postpolymerization modification of polymers produced by living polymerization is an attractive method to create precision nanomaterials. We describe the living cationic ring-opening polymerization of a 2-alkylthio-2-oxazoline to furnish a polythiocarbamate. The polythiocarbamate is activated toward substitution by N- and S-nucleophiles via oxidation of the S to an SO2. Mild substitution conditions provide broad functional group tolerance, constituting a versatile postpolymerization modification platform with access to a diversity of polyureas and polythiocarbamates. We further demonstrate the utility of this strategy by synthesizing and functionalizing block copolymers.
Stabilization of Azapeptides by Namide···H-NamideHydrogen Bonds
Baruah, Kalpita,Sahariah, Biswajit,Sakpal, Sushil S.,Deka, Jugal Kishore Rai,Bar, Arun Kumar,Bagchi, Sayan,Sarma, Bani Kanta
supporting information, p. 4949 - 4954 (2021/06/28)
An unusual Namide···H-Namide hydrogen bond (HB) was previously proposed to stabilize the azapeptide β-Turns. Herein we provide experimental evidence for the Namide···H-Namide HB and show that this HB endows a stabilization of 1-3 kcal·mol-1 and enforces the trans-cis-Trans (t-c-T) and cis-cis-Trans (c-c-T) amide bond conformations in azapeptides and N-methyl-Azapeptides, respectively. Our results indicate that these Namide···H-Namide HBs can have stabilizing contributions even in short azapeptides that cannot fold to form β-Turns.
Synthesis and application of isocyanates radiolabeled with carbon-11
Wilson, Alan A.,Garcia, Armando,Houle, Sylvain,Sadovski, Oleg,Vasdev, Neil
supporting information; experimental part, p. 259 - 264 (2011/03/19)
Carbon-11 labeled isocyanates are efficiently prepared by dehydration of [11C]carbamate salts, which in turn are easily formed from cyclotron-produced [11C]CO2 and amines in the presence of a CO2 fixation agent. The [11C]isocyanates are useful radiosynthons for the synthesis of a variety of [carbonyl-11C]- labeled asymmetrical ureas and carbamate esters. The method is well suited to incorporate any isotope of carbon, and is especially useful for positron emission tomography (PET) radiotracers for in vivo imaging. This is demonstrated by using the method to make [carbonyl-11C]-6-hydroxy-[1,1′- biphenyl]-3-yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase.
OXYGEN ATOM TRANSFER TO METAL ISOCYANIDE. KINETICS AND MECHANISM OF OXYGEN ATOM TRANSFER OF (CH3)3NO TO BENZYL ISOCYANIDE IN Br2
Shen, Jian-Kun,Wang, Wei-Bo,Gao, Yi-Ci,Shi, Qi-Zhen,Roskamp, Eric J.,Basolo, Fred
, p. 225 - 228 (2007/10/02)
Reported are results from the first investigation on the reaction of Me3NO with metal isocyanides.The reaction of Br2 with Me3NO yields +.The side products derived from trimethylamine N-oxide, trimethylamine and dimethyliminium ion were transformed and characterized as ammonium chlorides.Kinetic studies show that the reaction is first order in the concentration of the iron complexes and of trimethylamine N-oxide.This and activation parameters, ΔH(excit.) = 22.6 kcal/mol and ΔS(excit.) = 4.7 cal/mol K, suggest an associative rate-determining step.
