82480-87-3Relevant academic research and scientific papers
A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas
Smith, Keith,El-Hiti, Gamal A.,Hegazy, Amany S.,Kariuki, Benson
supporting information; experimental part, p. 1219 - 1227 (2011/11/05)
Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.
One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas
Smith, Keith,El-Hiti, Gamal A.,Hegazy, Amany S.
supporting information; experimental part, p. 2790 - 2792 (2010/09/04)
Lithiation of various N′-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 °C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.
PHOTOREDUCTION DE LA BENZOPHENONE PAR DES PHTALIMIDINES ET DES DIHYDRO ISOQUINOLONES. ETUDE CHIMIQUE ET PAR RMN PNIC
Gramain, J. C.,Simonet, N.,Vermeersch, G.,Febvay-Garot, N.,Caplain, S.,Lablache-Combier, A.
, p. 539 - 550 (2007/10/02)
Benzophenone is photoreduced by phtalimidines and dihydro isoquinolones.The hydrogen atom α to the nitrogen atom is abstracted and radical coupling leads to adducts.CIDNP studies of these adducts show inversion of polarisation for the adduct on the N-alkyl chain when the nitrogen is bound to a benzylic methylene.This inversion is explained by considering that the radical on the N-alkyl chain derives from the radical on the ring.
