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353763-06-1

4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 353763-06-1 Structure

  • Basic information

    1. Product Name: 4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one
    2. Synonyms: 4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one;(4E)-4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one
    3. CAS NO:353763-06-1
    4. Molecular Formula: C24H20N2O2
    5. Molecular Weight: 368.4278
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 353763-06-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one(353763-06-1)
    11. EPA Substance Registry System: 4-(4-ethoxybenzylidene)-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one(353763-06-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 353763-06-1(Hazardous Substances Data)

353763-06-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 353763-06-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,3,7,6 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 353763-06:
(8*3)+(7*5)+(6*3)+(5*7)+(4*6)+(3*3)+(2*0)+(1*6)=151
151 % 10 = 1
So 353763-06-1 is a valid CAS Registry Number.

353763-06-1Downstream Products

353763-06-1Relevant articles and documents

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors

Dong, Guoqiang,Han, Guiyan,Li, Chenglan,Liu, Na,Liu, Yang,Sheng, Chunquan,Tu, Jie,Wu, Shanchao

, (2020)

Secreted aspartic protease 2 (SAP2), a kind of virulence factor, is an emerging new antifungal target. Using docking-based virtual screening and structure-based inhibitor design, a series of novel SAP2 inhibitors were successfully identified. Among them, indolone derivative 24a showed potent SAP2 inhibitory activity (IC50 = 0.92 μM). It blocked fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1. As a virulence factor inhibitor, compound 24a was inactive in vitro and showed potent in vivo efficacy in a murine model of invasive candidiasis. It represents a promising lead compound for the discovery of novel antifungal agents.

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